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Follicular atresia is predominantly regulated by apoptosis of granulosa cells, but the mechanism underlying apoptosis via the mitochondria\u2010dependent apoptotic pathway is unclear. We aimed to investigate whether the mitochondria\u2010associated genes peroxisome proliferator\u2010activated receptor\u2010gamma, coactivator1\u2010alpha (<jats:italic><jats:styled-content style=\"fixed-case\">PPARGC<\/jats:styled-content>1A<\/jats:italic>), nuclear respiratory factor\u20101 (<jats:italic><jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>\u20101<\/jats:italic>), B\u2010cell <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/lymphoma 2 (<jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102<\/jats:italic>) and <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2\u2010associated X protein (<jats:italic><jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content><\/jats:italic>) played a role in follicular atresia through this pathway. The four mitochondria\u2010associated proteins (<jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\u20101<jats:italic>\u03b1<\/jats:italic>, which are encoded by the <jats:italic><jats:styled-content style=\"fixed-case\">PPARGC<\/jats:styled-content>1A<\/jats:italic> gene, <jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102 and <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content>) mainly expressed in granulosa cells. The <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein levels of <jats:italic><jats:styled-content style=\"fixed-case\">PPARGC<\/jats:styled-content>1A<\/jats:italic>\/<jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\u20101<jats:italic>\u03b1<\/jats:italic> and <jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>\u20101 in granulosa cells increased with the follicular development. These results showed that these genes may play a role in the regulation of the follicular development. In addition, compared with healthy follicles, the granulosa cell in atretic follicles had a reduced expression of <jats:styled-content style=\"fixed-case\">NRF<\/jats:styled-content>\u20101, increased <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content> expression and increased ratio of <jats:styled-content style=\"fixed-case\">BAX<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\u20102 expression. These results suggested that changes of the mitochondria\u2010associated gene expression patterns in granulosa cells may lead to follicular atresia during goat follicle development.<\/jats:p>","DOI":"10.1111\/rda.12514","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T05:35:23Z","timestamp":1426570523000},"page":"465-473","source":"Crossref","is-referenced-by-count":37,"title":["Expression of Mitochondria\u2010Associated Genes (<i><scp>PPARGC<\/scp>1A<\/i>,<i><scp>NRF<\/scp>\u20101<\/i>,<i><scp>BCL<\/scp>\u20102<\/i> and <i><scp>BAX<\/scp><\/i>) in Follicular Development and Atresia of Goat Ovaries"],"prefix":"10.1111","volume":"50","author":[{"given":"G","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Wan","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lan","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Jia","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fan","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Livestock Embryo Engineering Laboratory Nanjing Agricultural University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00768.2006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.031682"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.6.1779"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsgi.2004.01.015"},{"key":"e_1_2_9_6_1","first-page":"647","article-title":"The Bcl2 family: regulators of the cellular life\u2010or\u2010death switch. 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