{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:05Z","timestamp":1740126365818,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T00:00:00Z","timestamp":1433635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["APQ00373"],"award-info":[{"award-number":["APQ00373"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Intravaginal progesterone\u2010releasing devices are largely used both as contraceptives in humans and as a component of oestrous synchronization protocols in cattle. To reduce costs in large\u2010scale timed artificial insemination, the reuse of these releasing devices is common. Passive hormone diffusion, however, depends on the concentration gradient, which could affect the amount of residual progesterone present in these devices after a first use. To evaluate the effect of the presence of a corpus luteum in the release of progesterone from intravaginal devices, three synchronization protocols were designed to simulate the effects of inserting the device in the early dioestrus, late dioestrus or anoestrus. Holstein\u2010Zebu cross\u2010bred heifers were randomly allocated into one of these three treatments, and a series of blood samples was taken to evaluate the plasma progesterone concentrations. After 8\u00a0days, the intravaginal devices were removed and underwent a previously validated alcoholic extraction technique to measure the residual progesterone. Non\u2010used devices were used as controls. As expected, the simultaneous presence of the intravaginal device and a corpus luteum resulted in increased plasma progesterone concentrations. Conversely, the amount of residual progesterone in the devices after use was inversely proportional to the plasma progesterone concentration. These results demonstrate that the release rate of progesterone from intravaginal devices is affected by the endogenous concentration of this hormone; consequently, the strategy for reuse should account for the category and expected luteal cyclic activity of the animals undergoing synchronization protocols.<\/jats:p>","DOI":"10.1111\/rda.12550","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T14:17:07Z","timestamp":1433859427000},"page":"692-695","source":"Crossref","is-referenced-by-count":1,"title":["Endogenous Progesterone Concentrations Affect Progesterone Release from Intravaginal Devices Used for Oestrous Synchronization in Cattle"],"prefix":"10.1111","volume":"50","author":[{"given":"HL","family":"Neri","sequence":"first","affiliation":[{"name":"University of Alfenas Alfenas MG Brazil"},{"name":"Hertape\u2010Calier Juatuba MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MP","family":"Palhao","sequence":"additional","affiliation":[{"name":"University of Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DS","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul MS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JHM","family":"Viana","sequence":"additional","affiliation":[{"name":"University of Alfenas Alfenas MG Brazil"},{"name":"Embrapa Juiz de Fora MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAC","family":"Fernandes","sequence":"additional","affiliation":[{"name":"University of Alfenas Alfenas MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4320(92)90049-J"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2003.09.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2009-2349"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00178-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.02.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD11917"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(95)00279-H"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.02.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(00)00276-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2007.06.006"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12550","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:23:19Z","timestamp":1696202599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/rda.12550"],"URL":"https:\/\/doi.org\/10.1111\/rda.12550","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"type":"print","value":"0936-6768"},{"type":"electronic","value":"1439-0531"}],"subject":[],"published":{"date-parts":[[2015,6,7]]}}}