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The use of antibiotics, however, is not an appropriate compensation for a lack of hygiene standards in artificial insemination (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>) centres. Sophisticated hygiene management and the proper identification of hygienic critical control points (<jats:styled-content style=\"fixed-case\">HCCP<\/jats:styled-content>s) at <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> centres provide the basis for counteracting the development of antibiotic resistance in contaminant bacteria and their settlement in <jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content> centres. In recent years, efforts have been made to use antimicrobial peptides (<jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>s) in the preservation of boar semen. Investigations have included the testing of synthetic magainin derivatives and cyclic hexapeptides. One prerequisite for the application of <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>s is that they have a minor impact on eukaryotic cells. Bacterial selectivity, proteolytic stability, thermodynamic resistance, and mechanisms including synergistic interaction with conventional antibiotics have made cyclic hexapeptides highly promising candidates for potential application as peptide antibiotics for semen preservation.<\/jats:p>","DOI":"10.1111\/rda.12553","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T05:23:21Z","timestamp":1437024201000},"page":"5-10","source":"Crossref","is-referenced-by-count":17,"title":["Challenges and Limits Using Antimicrobial Peptides in Boar Semen Preservation"],"prefix":"10.1111","volume":"50","author":[{"given":"M","family":"Schulze","sequence":"first","affiliation":[{"name":"Institute for the Reproduction of Farm Animals Sch\u00f6now Inc. 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