{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:50:03Z","timestamp":1770137403731,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T00:00:00Z","timestamp":1434067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Contents<\/jats:title>A 14\u2010month\u2010old Japanese Black heifer was evaluated on Day 0 (D 0) for enlargement of the right ovary (RO<\/jats:styled-content>). Transrectal ultrasonography (TRUS<\/jats:styled-content>) revealed that theRO<\/jats:styled-content>was markedly enlarged and multicystic, while the left ovary (LO<\/jats:styled-content>) was small and inactive. The presumptive diagnosis was granulosa\u2010theca cell tumour (GTCT<\/jats:styled-content>), which was confirmed by markedly elevated plasma anti\u2010M\u00fcllerian hormone (AMH<\/jats:styled-content>) of 4.42\u00a0ng\/ml. Therefore, ovariectomy of theRO<\/jats:styled-content>was the treatment of choice. The heifer was checked byTRUS<\/jats:styled-content>and blood sampling on D 42, D 63 and immediately before ovariectomy on D 85. On D 42,TRUS<\/jats:styled-content>did not show marked changes in either ovary in comparison with D 0. However, on D 63, theRO<\/jats:styled-content>had transformed into a single cyst, and on D 85, theLO<\/jats:styled-content>had resumed cyclic activity. TheRO<\/jats:styled-content>was extracted on D 85 by hand\u2010assisted laparoscopic ovariectomy to allow better control. Unexpectedly, histopathology revealed the lesion to be a fluid\u2010filled cystic structure, with no neoplastic proliferation of follicular epithelium that would indicateGTCT<\/jats:styled-content>. The wall of the cystic structure consisted of collagen fibres and a few degenerated granulosa cells. The retrospective hormonal analysis revealed that theAMH<\/jats:styled-content>concentrations had markedly dropped on D 63 and 85, which coincided with resumption of cyclicity in theLO<\/jats:styled-content>. These findings suggest that theGTCT<\/jats:styled-content>had self\u2010cured and transformed into a cyst\u2010like structure. The heifer then received an oestrous synchronization regime on D 105, was artificially inseminated on D 115 and became pregnant.<\/jats:p>","DOI":"10.1111\/rda.12555","type":"journal-article","created":{"date-parts":[[2015,6,20]],"date-time":"2015-06-20T00:51:37Z","timestamp":1434761497000},"page":"696-703","source":"Crossref","is-referenced-by-count":6,"title":["Evidence of Spontaneous Recovery of Granulosa\u2010Theca Cell Tumour in a Heifer: A Retrospective Report"],"prefix":"10.1111","volume":"50","author":[{"given":"H","family":"El\u2010Sheikh Ali","sequence":"first","affiliation":[{"name":"Laboratory of Theriogenology Department of Veterinary Sciences Faculty of Agriculture University of Miyazaki Miyazaki Japan"},{"name":"Department of Theriogenology Faculty of Veterinary Medicine University of Mansoura Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Laboratory of Theriogenology 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