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Non\u2010pregnant cows (n\u00a0=\u00a0188) with mature corpus luteum were treated with cloprostenol and 3\u00a0days later if they did not show oestrus, were examined by rectal palpation. Animals showing PVD (n\u00a0=\u00a060\/31.9%\/) and 14 controls with normal vaginal discharge (Score 0) were randomly selected and further examined by ultrasonography and blood samples were collected for detecting Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and transcervical guarded swabs were collected from the uterus for bacteriological examination. Although the majority of the examined animals were infected with Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 and <jats:italic>H.\u00a0somni<\/jats:italic> including the control animals as well, in group of animals with PVD score 3, fewer animals became pregnant and the duration between the first treatment to pregnancy was significantly extended. Based on these clinical and comparative data, our results confirm that these two microorganisms together may impair important reproductive parameters which may cause large economic losses to dairy farms.<\/jats:p>","DOI":"10.1111\/rda.12658","type":"journal-article","created":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T08:42:16Z","timestamp":1450773736000},"page":"143-149","source":"Crossref","is-referenced-by-count":12,"title":["Co\u2010infection with Bovine Herpesvirus 4 and <i>Histophilus somni<\/i> Significantly Extends the Service Period in Dairy Cattle with Purulent Vaginal Discharge"],"prefix":"10.1111","volume":"51","author":[{"given":"O","family":"Szenci","sequence":"first","affiliation":[{"name":"MTA\u2010SZIE Large Animal Clinical Research Group \u00dcll\u0151\u2010D\u00f3ra major Hungary"},{"name":"Department and Clinic for Production Animals Faculty of Veterinary Science Szent Istv\u00e1n University \u00dcll\u0151\u2010D\u00f3ra major Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Sassi","sequence":"additional","affiliation":[{"name":"Department and Clinic for Production Animals Faculty of Veterinary Science Szent Istv\u00e1n University \u00dcll\u0151\u2010D\u00f3ra major Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department and Clinic for Production Animals Faculty of Veterinary Science Szent Istv\u00e1n University \u00dcll\u0151\u2010D\u00f3ra major Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Szel\u00e9nyi","sequence":"additional","affiliation":[{"name":"MTA\u2010SZIE Large Animal Clinical Research Group \u00dcll\u0151\u2010D\u00f3ra major Hungary"},{"name":"Department and Clinic for Production Animals Faculty of Veterinary Science Szent Istv\u00e1n University \u00dcll\u0151\u2010D\u00f3ra major Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tibold","sequence":"additional","affiliation":[{"name":"Agroproduct Zrt P\u00e1pa Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"M\u00e1dl","sequence":"additional","affiliation":[{"name":"Agroproduct Zrt P\u00e1pa Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Egyed","sequence":"additional","affiliation":[{"name":"Agricultural Research Center Veterinary Medical Research Institute Hungarian Academy of Sciences Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511527104"},{"key":"e_1_2_7_3_1","first-page":"357","article-title":"Isolation of a bovine herpesvirus from calves with respiratory disease and keratoconjunctivitis","volume":"16","author":"Bartha A","year":"1966","journal-title":"Acta Vet Hung"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00614-06"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00717-15"},{"key":"e_1_2_7_6_1","first-page":"168","article-title":"Endometrial biopsy in Holstein\u2010Friesian dairy cows. 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