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Activation or blockade of <jats:italic>\u03bc<\/jats:italic>\u2010opioid receptors significantly decreased or increased the Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> concentration and Gn<jats:styled-content style=\"fixed-case\">RHR<\/jats:styled-content> abundance in the hypothalamus, respectively, and affected in the same way Gn<jats:styled-content style=\"fixed-case\">RHR<\/jats:styled-content> quantity in the AP gland. The changes in the levels of Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> and Gn<jats:styled-content style=\"fixed-case\">RHR<\/jats:styled-content> after treatment with <jats:italic>\u03b2<\/jats:italic>\u2010endorphin as well as following action of naloxone were reflected in fluctuations of plasma <jats:styled-content style=\"fixed-case\">LH<\/jats:styled-content> concentrations. On the basis of these results, it is suggested that <jats:italic>\u03b2<\/jats:italic>\u2010endorphinergic system in the hypothalamus of follicular\u2010phase ewes affects directly or via <jats:italic>\u03b2<\/jats:italic>\u2010endorphin\u2010sensitive interneurons Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> and Gn<jats:styled-content style=\"fixed-case\">RHR<\/jats:styled-content> biosynthesis leading to suppression in secretory activity of the hypothalamic\u2010pituitary axis.<\/jats:p>","DOI":"10.1111\/rda.12719","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T07:05:35Z","timestamp":1466751935000},"page":"555-561","source":"Crossref","is-referenced-by-count":5,"title":["The Central Effect of <i>\u03b2<\/i>\u2010Endorphin and Naloxone on The Biosynthesis of Gn<scp>RH<\/scp> and Gn<scp>RH<\/scp> Receptor (Gn<scp>RHR<\/scp>) in The Hypothalamic\u2010Pituitary Unit of Follicular\u2010Phase Ewes"],"prefix":"10.1111","volume":"51","author":[{"given":"M","family":"Ciechanowska","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"\u0141apot","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mateusiak","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Paruszewska","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology The General Karol 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