{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:09:33Z","timestamp":1749614973824,"version":"3.41.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T00:00:00Z","timestamp":1471996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Dogs have been studied for several reasons, such as the genetic improvement, their use as experimental models, in zoonotic research, cell therapy and as a model for human diseases. However, many features relating to the embryonic development of dogs remain unknown because of the absence of embryological studies. Considering the importance of the cardiorespiratory system in the development of embryos, the aim of this study was to investigate the development of the main cardiorespiratory organs of dog embryos and foetuses with estimated gestational ages from 16 to 46\u00a0days using macro\u2010 and microscopic descriptions. On day 16 of development, the neural tube and crest were formed, the anterior and posterior neuropore closure had begun and the somites had developed. Between days 22 and 27 of gestation, the lung buds and the initial formation of the primary bronchi and heart chambers were observed. The heart chambers exhibited the endo\u2010, myo\u2010 and epicardial layers but did not have obvious differences in thickness among each other. Between days 41 and 46 of gestation, the nasal conchae and septa and trachea were formed, which exhibited characteristic epithelia. The lung formation and lobation were complete. The heart and major vessels exhibited mature histological architecture when their anatomical development was complete. The results of this study contribute to a more accurate definition of the embryonic and foetal developmental stages in dogs.<\/jats:p>","DOI":"10.1111\/rda.12759","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T04:27:17Z","timestamp":1472099237000},"page":"804-812","source":"Crossref","is-referenced-by-count":3,"title":["Development of the cardiorespiratory system in dogs from days 16 to 46 of pregnancy"],"prefix":"10.1111","volume":"51","author":[{"given":"AA","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Surgery School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PO","family":"Favaron","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"de Jesus Oliveira","sequence":"additional","affiliation":[{"name":"Department of Animal Science Faculty of Animal Sciences and Food Engineering University of Sao Paulo Pirassununga S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BT","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FD","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MA","family":"Miglino","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061367"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073136"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2014.08.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2460\/ajvr.1984.45.07.1259","article-title":"Preliminary study of the ultrasonic diagnosis of pregnancy and fetal development in dog","volume":"45","author":"Cartee R. 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