{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:42:21Z","timestamp":1791924141118,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Virbac France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>The gonadotropin\u2010releasing hormone (Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>) stimulation test is a common procedure used to investigate normality of the pituitary\u2010gonadal axis in mammals. There is very little information on the technique, its efficacy and side effects in small animals and in particular no information for male cats. In dogs, such test is performed by intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) administration. With cats, the number of times the animal needs to be restrained for blood sampling should be the least possible. The purpose of this study was to assess efficacy and side effects of the Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>stimulation test in tomcats comparing the<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>with the intramuscular (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) route of administration. A Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>stimulation test was performed in eight adult tomcats through<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>administration of 50\u00a0\u03bcg gonadorelin. The response of the pituitary\u2010gonadal axis was assessed by measuring serum testosterone on blood samples collected prior to and 1\u00a0hr following treatment. When considering each single group of cats, the post\u2010stimulation serum testosterone values were significantly higher than the pre\u2010treatment ones (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). When comparing the two groups of cats, basal testosterone concentrations did not differ, and also post\u2010Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>testosterone concentrations did not differ. In conclusion, in the cats of our study, the Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>stimulation test produced the same results following the<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>or the<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>route of administration. Therefore, in tomcats, the<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>route can be considered as effective as the<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>one and should be preferred when doing a Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>test.<\/jats:p>","DOI":"10.1111\/rda.12771","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T12:09:11Z","timestamp":1479125351000},"page":"24-27","source":"Crossref","is-referenced-by-count":8,"title":["Use of the gonadotropin\u2010releasing hormone (GnRH) stimulation test to monitor gonadal function in intact adult male cats"],"prefix":"10.1111","volume":"52","author":[{"given":"S","family":"Romagnoli","sequence":"first","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Baldan","sequence":"additional","affiliation":[{"name":"Private Practitioner Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Righetti","sequence":"additional","affiliation":[{"name":"Private Practitioner Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Companion Animal Medical Department \u2010 Virbac group Carros France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Scenna","sequence":"additional","affiliation":[{"name":"Private Practitioner Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Badon","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Stelletta","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Milani","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cecchetto","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mollo","sequence":"additional","affiliation":[{"name":"Department of Animal Medicine, Production and Health University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.10.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0520201"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.072S148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1050175"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.10.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01933.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/j.1939-4640.1990.tb03229.x","article-title":"Teratospermic and normospermic domestic cats: Ejaculate traits, pituitary\u2010gonadal hormones, and improvement of spermatozoal motility and morphology after swim\u2010up processing","volume":"11","author":"Howard J. 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