{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:09Z","timestamp":1787016069087,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T00:00:00Z","timestamp":1480464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jonnie Bernard Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Contents<\/jats:title>\n \n Measurement of circulating luteinizing hormone (\n LH<\/jats:styled-content>\n ) concentrations in cats and temporal changes following ovariohysterectomy (\n OHE<\/jats:styled-content>\n ) or possibly Gn\n RH<\/jats:styled-content>\n vaccination may be informative for assessing their fertility, contraception or sterilization status. In this study, serum\n LH<\/jats:styled-content>\n concentrations were measured in domestic cats (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 6) immediately prior to and up to 120\u00a0days post\u2010\n OHE<\/jats:styled-content>\n . Basal\n LH<\/jats:styled-content>\n concentrations of females previously subjected to\n OHE<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 4; ~1.5\u00a0years post\u2010\n OHE<\/jats:styled-content>\n ) were compared pre\u2010 and post\u2010vaccination with a Gn\n RH<\/jats:styled-content>\n immunocontraceptive, and to\n LH<\/jats:styled-content>\n concentrations in intact females. Basal serum\n LH<\/jats:styled-content>\n concentrations (2.67\u00a0\u00b1\u00a00.43\u00a0ng\/ml; mean\u00a0\u00b1\u00a0\n SEM<\/jats:styled-content>\n ) in intact females increased (\n p<\/jats:italic>\n \u00a0<\u00a0.01) by 30\u00a0days post\u2010\n OHE<\/jats:styled-content>\n (5.65\u00a0\u00b1\u00a00.87\u00a0ng\/ml) but then declined (\n p<\/jats:italic>\n \u00a0<\u00a0.05) to pre\u2010\n OHE<\/jats:styled-content>\n levels (mean range, 3.26\u20133.62\u00a0ng\/ml) at days 60\u2013120 post\u2010\n OHE<\/jats:styled-content>\n . Serum\n LH<\/jats:styled-content>\n (3.84\u00a0\u00b1\u00a00.51\u00a0ng\/ml) in four females ~1.5\u00a0years after\n OHE<\/jats:styled-content>\n tended to be higher (\n p\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n .10) than those of intact females prior to\n OHE<\/jats:styled-content>\n . Three months following first or second Gn\n RH<\/jats:styled-content>\n immunocontraceptive vaccine treatment, serum\n LH<\/jats:styled-content>\n values in females previously subjected to\n OHE<\/jats:styled-content>\n decreased (\n p<\/jats:italic>\n \u00a0<\u00a0.05) to concentrations similar to those observed in intact females. Our preliminary results suggest that\n OHE<\/jats:styled-content>\n of domestic cats causes a marked increase in basal\n LH<\/jats:styled-content>\n levels within the first few weeks after ovariohysterectomy followed by a return to pre\u2010\n OHE<\/jats:styled-content>\n basal values over the next several months. Reduced\n LH<\/jats:styled-content>\n concentrations after Gn\n RH<\/jats:styled-content>\n vaccine may indicate the effectiveness of the immunocontraceptive in reducing the circulating levels of Gn\n RH<\/jats:styled-content>\n , thereby reducing secretion of\n LH<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/rda.12840","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T23:43:17Z","timestamp":1480549397000},"page":"332-335","source":"Crossref","is-referenced-by-count":5,"title":["Temporal changes in serum luteinizing hormone following ovariohysterectomy and gonadotropin\u2010releasing hormone vaccination in domestic cats"],"prefix":"10.1111","volume":"52","author":[{"given":"HL","family":"Bateman","sequence":"first","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife (CREW) Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LM","family":"Vansandt","sequence":"additional","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife (CREW) Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Newsom","sequence":"additional","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife (CREW) Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WF","family":"Swanson","sequence":"additional","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife (CREW) Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2014.11.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(82)50008-3"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod40.6.1179"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.10.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/zoo.10051"},{"key":"e_1_2_7_7_1","first-page":"97","article-title":"Importance of testicular hormones in maintaining the annual pattern of LH secretion in the male horse","volume":"32","author":"Irvine C. H.","year":"1982","journal-title":"Journal of Reproduction and Fertility. Supplement"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-1-240"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-109-1-247"},{"key":"e_1_2_7_10_1","first-page":"91","volume-title":"Biology of Reproduction","author":"Magarey G. M.","year":"2005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2004.09.047"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.06.027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00328"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-96-4-854"},{"key":"e_1_2_7_15_1","unstructured":"Vansandt L. Kutzler M. Fischer A. Morris K. &Swanson W.(In Press).Safety and effectiveness of a single and repeat intramuscular injection of a GnRH vaccine (GonaCon\u2122) in adult female domestic cats. Under Review. Reproduction in Domestic Animals."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod25.1.15"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12840","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12840","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T03:47:53Z","timestamp":1694576873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,30]]},"references-count":15,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/rda.12840"],"URL":"https:\/\/doi.org\/10.1111\/rda.12840","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,30]]}}}