{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:37:53Z","timestamp":1791499073673,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Alliance for Contraception in Cats & Dogs"},{"name":"Joanie Bernard Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Contents<\/jats:title>\n                  <jats:p>\n                    Sterilization is a key strategy to reduce the number of domestic cats entering and killed in shelters each year. However, surgical sterilization is expensive and labour\u2010intensive and cannot fully address the 70 million free\u2010roaming cats estimated to exist in the United States. GonaCon\u2122 is a gonadotropin\u2010releasing hormone vaccine originally developed for use as a wildlife immunocontraceptive. An earlier formulation was tested in domestic cats and found to be safe and effective for long\u2010term contraception. However, the current Environmental Protection Agency (\n                    <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>\n                    )\u2010registered formulation consists of a different antigen\u2010carrier protein and increased antigen concentration and has never been tested in cats. A pilot study was undertaken to evaluate the short\u2010term safety of a single GonaCon immunization, assess the consequences of vaccinated cats receiving an accidental second GonaCon injection and determine the humoral immune response to immunization. During Phase 1, cats in Group A (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03) received a single intramuscular injection of GonaCon and Group B (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03) received a single intramuscular injection of saline. During Phase 2, Group A received a second GonaCon injection and Group B received their initial GonaCon injection. All cats developed Gn\n                    <jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content>\n                    antibodies within 30\u00a0days of vaccine administration. The endpoint titre (1:1,024,000) was similar among all cats, and levels remained high throughout the duration of the study. Four cats developed a sterile, painless, self\u2010limiting mass at the site of injection. The mean number of days to mass development was 110.3 (range, 18\u2013249\u00a0days). In conclusion, this preliminary study suggests that the\n                    <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>\n                    \u2010registered GonaCon formulation is safe for continued testing in domestic cats, an accidental revaccination should not increase the risk of a vaccine reaction and the\n                    <jats:styled-content style=\"fixed-case\">EPA<\/jats:styled-content>\n                    \u2010registered formulation effectively elicits a strong humoral immune response.\n                  <\/jats:p>","DOI":"10.1111\/rda.12853","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T13:08:30Z","timestamp":1479301710000},"page":"348-353","source":"Crossref","is-referenced-by-count":16,"title":["Safety and effectiveness of a single and repeat intramuscular injection of a Gn\n                    <scp>RH<\/scp>\n                    vaccine (GonaCon\u2122) in adult female domestic cats"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5951-2057","authenticated-orcid":false,"given":"LM","family":"Vansandt","sequence":"first","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Kutzler","sequence":"additional","affiliation":[{"name":"Department of Animal and Rangeland Sciences Oregon State University Corvallis OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AE","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Illinois Urbana IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KN","family":"Morris","sequence":"additional","affiliation":[{"name":"Institute for Human\u2010Animal Connection Graduate School of Social Work University of Denver Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WF","family":"Swanson","sequence":"additional","affiliation":[{"name":"Center for Conservation and Research of Endangered Wildlife Cincinnati Zoo and Botanical Garden Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Society for the Prevention of Cruelty to Animals (ASPCA)(2016).Pet statistics: Shelter intake and surrender. Retrieved fromhttp:\/\/www.aspca.org\/animal-homelessness\/shelter-intake-and-surrender\/pet-statistics"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12840"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15594989"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.220.1627"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.248.3.298"},{"key":"e_1_2_7_7_1","unstructured":"Griffin B. Baker H. Welles E. Miller L. &Fagerstone K.(2004).Response of dogs to a GNRH\u2010KLH conjugate contraceptive vaccine adjuvanted with AdjuVac.Second International Symposium on Nonsurgical Methods for Pet Population Control. Breckenridge CO. pp.189\u2013190."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.9.1134"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327604JAWS0501_2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327604JAWS0504_03"},{"key":"e_1_2_7_11_1","first-page":"71","article-title":"A report on trap\/alter\/release programs","author":"Johnson K. J.","year":"1996","journal-title":"Cat Fancier's Almanac"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.2460\/javma.1993.203.03.396","article-title":"Epidemiologic evidence for a causal relation between vaccination and fibrosarcoma tumorigenesis in cats","volume":"203","author":"Kass P. H.","year":"1993","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.225.1354"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.06.022"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.42"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.05.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2003.12.025"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.02.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113553"},{"key":"e_1_2_7_20_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.5070\/V423110577","article-title":"Immune mechanisms and characterization of injection site reactions involved in the multi\u2010year contraceptive effect of the GonaCon vaccine","volume":"23","author":"Miller L.","year":"2008","journal-title":"Proceedings of the Vertebrate Pest Conference"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2007.08.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13500429"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2002.221.1136"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(02)00022-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.225.1361"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12853","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12853","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T12:42:20Z","timestamp":1718887340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":24,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/rda.12853"],"URL":"https:\/\/doi.org\/10.1111\/rda.12853","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}