{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T05:27:29Z","timestamp":1768714049085,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009088","name":"Vetmeduni Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009088","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Diseases of the reproductive tract are a frequent problem in dairy herds. Herpesviruses are uterine pathogens also involved in other clinical diseases; for example, bovine herpesvirus type 4 Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 induces abortion, enteritis, metritis, pneumonia and vaginitis, but it can also be detected in healthy cows. The role of Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 in the development of clinical endometritis (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) or subclinical endometritis (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) has not clearly been described. Therefore, the objective of this study was to describe the prevalence of uterine Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 infection and its relationship with clinical, bacteriological and cytological findings in dairy cows 20\u201330\u00a0days after calving. The experiment was performed as a completely randomized block design, with farm (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>10) as blocking criterion and with cow (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>397) as the experimental unit. Logistic regression models were used to assess the effect of Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 infection on <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SE<\/jats:styled-content> and reproductive performance. Proportion of cows infected with Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 was 5.8% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>23\/397). Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 was isolated in 11.0% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>12\/109), 4.8% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4\/84) and 3.6% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>7\/194) of cows diagnosed as <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SE<\/jats:styled-content> or healthy, respectively. A logistic model revealed that Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 infection showed a tendency to increase the risk for <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a02.17; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.10) but significantly reduced both, the odds for artificial insemination within 80 days post\u2010partum (dpp) (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a00.37; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.035) and for pregnancy within 200\u00a0dpp (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a00.13; <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.004). Furthermore, Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 infection increased the chance for intrauterine infection with <jats:italic>Trueperella pyogenes<\/jats:italic> (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a05.55; <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001) and vice versa (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a05.79, <jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001). In conclusion, Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 infection is associated with reduced chances for insemination and pregnancy by 200\u00a0dpp and showed a trend to be associated with increased risk for <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>. Furthermore, Bo<jats:styled-content style=\"fixed-case\">HV<\/jats:styled-content>\u20104 and <jats:italic>Trueperella pyogenes<\/jats:italic> infections are strongly related.<\/jats:p>","DOI":"10.1111\/rda.12865","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T17:30:14Z","timestamp":1479317414000},"page":"115-121","source":"Crossref","is-referenced-by-count":15,"title":["Uterine infection with bovine herpesvirus type 4 in dairy cows"],"prefix":"10.1111","volume":"52","author":[{"given":"S","family":"Klamminger","sequence":"first","affiliation":[{"name":"Vetmeduni Vienna Department for Farm Animals and Veterinary Public Health University Clinic for Ruminants Clinical Unit for Herd Health Management Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Prunner","sequence":"additional","affiliation":[{"name":"Vetmeduni Vienna Department for Farm Animals and Veterinary Public Health University Clinic for 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