{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:33:14Z","timestamp":1784133194571,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>A three\u2010year\u2010old intact female Old English sheepdog was presented for evaluation of infertility. A uterine biopsy was performed during dioestrus, and the microscopic appearance was inconsistent with progesterone stimulation; the glands were sparse, simple and failed to show coiling, while the glandular epithelium was cuboidal instead of columnar. There was very little evidence of glandular activity. Due to the inappropriate appearance of the glands for the stage of the cycle, immunohistochemistry for progesterone receptors was performed. No progesterone receptor\u2010positive immunoreactivity was identified in the endometrial luminal epithelium, glandular epithelium or stroma. Weak intranuclear immunoreactivity was identified within the smooth muscle cells of the myometrium. The absence of progesterone receptors within the endometrial glands is the most likely explanation for the abnormal appearance of the endometrium and for this bitch's infertility. To our knowledge, this is the first report of endometrial progesterone receptor absence in a bitch.<\/jats:p>","DOI":"10.1111\/rda.12874","type":"journal-article","created":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T11:29:12Z","timestamp":1479122952000},"page":"174-178","source":"Crossref","is-referenced-by-count":2,"title":["Infertility associated with the absence of endometrial progesterone receptors in a bitch"],"prefix":"10.1111","volume":"52","author":[{"given":"JC","family":"Dockweiler","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Cossic","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CG","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RO","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Buckles","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SH","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Cornell University  Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.2.180"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.0.1240289"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/svms.2002.36601"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2004.04.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.09.005"},{"key":"e_1_2_7_7_1","first-page":"1","article-title":"Expression of progesterone receptors is significantly impaired in the endometrium of infertile women during the implantation window: A prospective observational study","volume":"3","author":"Petousis S.","year":"2016","journal-title":"Journal of Maternal Fetal and Neonatal Medicine"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(99)00273-3"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2012.01.016"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12874","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:55:09Z","timestamp":1695574509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/rda.12874"],"URL":"https:\/\/doi.org\/10.1111\/rda.12874","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}