{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:28:30Z","timestamp":1787315310003,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Saxon Animal Health Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Contents<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Coxiella burnetii<\/jats:italic>\n                    (C.\n                    <jats:italic>burnetii<\/jats:italic>\n                    ) is the causative agent of Q fever both in humans and animals. The objectives of this study were to investigate seropositivity and bacterial shedding in heifers and primiparous cows in an endemically infected herd and to assess the effects on post\u2010partum diseases, fertility and milk production. At the age of 9\u00a0months, 96 Holstein heifers were included. Sampling was performed reproduction\u2010orientated: at the beginning of the study, at detection of first pregnancy, 3\u00a0weeks before expected calving date (blood serum), at parturition and after 21, 42, 100 and 150\u00a0days in milk (\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    ) (blood serum, vaginal swabs and milk). Serum samples were investigated by a commercial\n                    <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\n                    for the presence of specific antibodies and vaginal swabs and milk samples by\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    to detect\n                    <jats:italic>C.\u00a0burnetii<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    . Individual animal data (calving ease, stillbirth, retained foetal membranes, puerperal metritis, endometritis after 42\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , presence of corpus luteum after 42\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , interval calving\u2010first service, interval calving\u2010conception, number of inseminations until 150\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , proportion of pregnant cows until 100 and 150\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , proportion of pregnant cows after first service and data of the dairy herd improvement test) were documented. All heifers were seronegative at the age of 9\u00a0months and 3\u00a0weeks before the expected calving date. Subsequently, the proportion of seropositive animals and the antibody score increased significantly towards 42 and 100\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , respectively. Vaginal\n                    <jats:italic>C.\u00a0burnetii<\/jats:italic>\n                    shedding was highest at parturition (30.9%), while the most positive milk samples were detected after 100\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    (15.3%).\n                    <jats:italic>Coxiella burnetii<\/jats:italic>\n                    seropositivity and shedding had no impact on parameters of reproduction. However, milk fat yield was declined in puerperal vaginal shedders and cows which seroconverted during their first 42\n                    <jats:styled-content style=\"fixed-case\">DIM<\/jats:styled-content>\n                    , respectively.\n                  <\/jats:p>","DOI":"10.1111\/rda.12878","type":"journal-article","created":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T11:52:09Z","timestamp":1481802729000},"page":"160-169","source":"Crossref","is-referenced-by-count":31,"title":["<i>Coxiella burnetii<\/i>\n                    : Serological reactions and bacterial shedding in primiparous dairy cows in an endemically infected herd\u2014impact on milk yield and fertility"],"prefix":"10.1111","volume":"52","author":[{"given":"M","family":"Freick","sequence":"first","affiliation":[{"name":"Veterinary Practice Zettlitz  Zettlitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Enbergs","sequence":"additional","affiliation":[{"name":"Saxon State Laboratory of Health and Veterinary Affairs  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Walraph","sequence":"additional","affiliation":[{"name":"Saxon State Laboratory of Health and Veterinary Affairs  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Diller","sequence":"additional","affiliation":[{"name":"Friedrich\u2010Loeffler\u2010Institute Institute of Bacterial Infections and Zoonoses (IBIZ)  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Weber","sequence":"additional","affiliation":[{"name":"Veterinary Practice Zettlitz  Zettlitz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Konrath","sequence":"additional","affiliation":[{"name":"Saxon State Laboratory of Health and Veterinary Affairs  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751\u20100147\u201055\u201013"},{"key":"e_1_2_8_3_1","unstructured":"Arbeitsgemeinschaft Deutscher Rinderz\u00fcchter e.V. (ADR). (2006).ADR\u2010Empfehlung 3.1 \u2010Leistungspr\u00fcfung f\u00fcr funktionale Merkmale bei Bullen und K\u00fchen (Gesundheit Reproduktion Nutzungsdauer Exterieur Melkbarkeit). Available online:http:\/\/www.adr-web.de\/richtlinien\/funktionale-merkmale.html?highlight=empfehlung+leistungspruefung+ funktionale+merkmale&. Accessed: 20.02.2016."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2007060"},{"key":"e_1_2_8_5_1","first-page":"427","article-title":"The impact of Q fever\u2010phase\u2010specific milk serology for the diagnosis of puerperal and chronic milk shedding of C.\u00a0burnetii in dairy cows","volume":"126","author":"B\u00f6ttcher J.","year":"2013","journal-title":"Berliner und Munchener Tierarztliche Wochenschrift"},{"key":"e_1_2_8_6_1","unstructured":"Conraths F. J. Fr\u00f6hlich A. Gethmann J. &Ziller M.(2015).Epidemiologische Untersuchungen in Tierpopulationen \u2013 Ein Leitfaden zur Bestimmung von Stichprobenumf\u00e4ngen 2nd ed. Available online:https:\/\/www.fli.de\/fileadmin\/FLI\/IfE\/Leitfaden_Bestimmung_von_Stichprobenumfaengen.pdf. Accessed: 02.03.2016."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2010.0575"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01788.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12095"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12333"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.4.2345-2352.2001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2007038"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.06.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.10.007"},{"key":"e_1_2_8_15_1","first-page":"572","volume-title":"Physiologie der Haustiere","author":"G\u00fcrtler H.","year":"2000"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.12.021"},{"key":"e_1_2_8_17_1","unstructured":"International Committee for Animal Recording (ICAR). (2014).ICAR recording guidelines. Available online:http:\/\/www.icar.org\/wp-content\/uploads\/2015\/11\/Guidelines_2014.pdf. Accessed: 25.02.2016."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02180-15"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2008.07.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-6-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.12.019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.04.026"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.10.038"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.518"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040023"},{"key":"e_1_2_8_26_1","unstructured":"Motsch B. Alves C. Janowetz B. Alex M. Meier N. &Boettcher J.(2016).Endemic infection with Coxiella burnetii in dairy cow herds follows a defined cycle. Proceedings of the 29th World Buiatrics Congress Dublin Ireland 3\u20138 July 2016 369."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500419102"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.03.003"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbed.12423"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144608"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68266-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.12261"},{"key":"e_1_2_8_33_1","first-page":"367","article-title":"Sonographical visibility of the corpus luteum in dairy cows","volume":"40","author":"R\u00f6skes S.","year":"2012","journal-title":"Tier\u00e4rztl Prax G"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00690-08"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-008-8059-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.08.021"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268811002275"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2011.05.005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1556\/004.2015.031"},{"key":"e_1_2_8_40_1","first-page":"50","article-title":"Judging a Plethora of p\u2010values: How to contend with the problem of multiple testing. Part 10 of a series on evaluation of scientific publications","volume":"107","author":"Victor A.","year":"2010","journal-title":"Deutsches \u00c4rzteblatt International"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.12878","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.12878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:54:44Z","timestamp":1695560084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.12878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,15]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/rda.12878"],"URL":"https:\/\/doi.org\/10.1111\/rda.12878","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,15]]}}}