{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:50Z","timestamp":1762324070103,"version":"3.37.3"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"UWM in Olsztyn, Poland","award":["12.610.005-300."],"award-info":[{"award-number":["12.610.005-300."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>methylation is maintained by the main elements of methylation complex\u2014tripartite motif containing 28 (<jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28) and zinc finger protein 57 (<jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57). Previously, it was found that the activity of<jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28 and<jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57 determines the process of<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>methylation and preserves over\u2010expression of genes. We hypothesized that restricted diet applied during peri\u2010conceptional period may induce changes in the expression of methylation complex in porcine endometrium and embryos during the peri\u2010implantation period. The aim of this study was to detect and determine the expression of<jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28 and<jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57 in the endometrium and embryos harvested from gilts during the peri\u2010implantation period (days 15\u201316 of pregnancy) fed restricted (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) or normal (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) diet during peri\u2010conceptional period. In restricted\u2010diet\u2010fed gilts, endometrial expression of<jats:italic><jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57<\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s was decreased in comparison with normal\u2010diet\u2010fed gilts (<jats:italic>p\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>.01), while the embryonic expression of<jats:italic><jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28<\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57<\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content>s was increased in restricted\u2010diet\u2010fed gilts (<jats:italic>p\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>.05). The immunofluorescence showed the presence of<jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28 and<jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57 in luminal epithelial (<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>), glandular epithelial (<jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>) and stromal cells (<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>) of the endometrium as well as in the embryos. Total endometrial and embryonic abundance of<jats:styled-content style=\"fixed-case\">TRIM<\/jats:styled-content>28 and<jats:styled-content style=\"fixed-case\">ZFP<\/jats:styled-content>57 proteins was significantly higher (<jats:italic>p\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>.05) in restricted\u2010diet\u2010fed gilts than in normal\u2010diet\u2010fed gilts. Female under\u2010nutrition during peri\u2010conceptional period affects the expression of two main elements of methylation complex in the endometrium and in embryos during the peri\u2010implantation period and may have the impact on<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>methylation in these tissues.<\/jats:p>","DOI":"10.1111\/rda.12943","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:18:49Z","timestamp":1489166329000},"page":"542-550","source":"Crossref","is-referenced-by-count":10,"title":["Peri\u2010conceptional under\u2010nutrition alters the expression of<scp>TRIM<\/scp>28 and<scp>ZFP<\/scp>57 in the endometrium and embryos during peri\u2010implantation period in domestic pigs"],"prefix":"10.1111","volume":"52","author":[{"given":"K","family":"Zglejc","sequence":"first","affiliation":[{"name":"Department of Animal Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-8207","authenticated-orcid":false,"given":"A","family":"Franczak","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"volume-title":"Mothers, babies and health in later life","year":"1998","author":"Baker D. 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