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However, until now the pathogenesis of the endometritis in the bitch is unclear. The aim of this study was to evaluate the gene transcription pattern of prostaglandin (PG<\/jats:styled-content>) synthesis enzymes (cyclooxygenase [COX<\/jats:styled-content>2], PTGES<\/jats:styled-content>\u20101 and PGFS<\/jats:styled-content>) in the endometrium of bitches with or without endometritis. Thirty mixed breed bitches in dioestrus, aged between 1 and 5\u00a0years, and weighing between 10 and 30\u00a0kg were used. After ovariohysterectomy (OVX<\/jats:styled-content>), uterine biopsy samples were collected from the middle part of both horns. Then, endometrial epithelium was collected using the cytobrush method and mRNA<\/jats:styled-content> analysis was performed by real\u2010time RT<\/jats:styled-content>\u2010PCR<\/jats:styled-content>. Data were analysed with Kruskal\u2013Wallis anova<\/jats:sc> using the sas<\/jats:sc>\u00ae<\/jats:sup> software. Uterine condition was identified by endometrial biopsies (normal endometria [n<\/jats:italic>\u00a0=\u00a011; NE<\/jats:styled-content>], acute endometritis [n<\/jats:italic>\u00a0=\u00a010; AE<\/jats:styled-content>] and chronic endometritis [n<\/jats:italic>\u00a0=\u00a09; CE<\/jats:styled-content>]). The COX<\/jats:styled-content>2, PTGES<\/jats:styled-content>\u20101 and PGFS<\/jats:styled-content>\/AKR<\/jats:styled-content>1C3 mRNA<\/jats:styled-content> expression in bitches with and without endometritis was similar. Except for PGFS<\/jats:styled-content>\/AKR<\/jats:styled-content>1C3, gene transcription of COX<\/jats:styled-content>2 and PTGES<\/jats:styled-content>\u20101 was significantly increased in AE<\/jats:styled-content> compared with CE<\/jats:styled-content>. In addition, COX<\/jats:styled-content>2 gene transcription was significantly increased in AE<\/jats:styled-content> compared with NE<\/jats:styled-content>. In contrast, no differences were found for COX<\/jats:styled-content>2, PTGES<\/jats:styled-content>\u20101 and PGFS<\/jats:styled-content>\/AKR<\/jats:styled-content>1C3 mRNA<\/jats:styled-content> expression in the samples of NE<\/jats:styled-content> compared with CE.<\/jats:p>","DOI":"10.1111\/rda.12950","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T09:21:01Z","timestamp":1491988861000},"page":"298-302","source":"Crossref","is-referenced-by-count":7,"title":["Prostaglandin synthesis enzymes' gene transcription in bitches with endometritis"],"prefix":"10.1111","volume":"52","author":[{"given":"MC","family":"Garc\u00eda Mitacek","sequence":"first","affiliation":[{"name":"C\u00e1tedra y Servicio de Reproducci\u00f3n Animal Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata Argentina"},{"name":"CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RG","family":"Praderio","sequence":"additional","affiliation":[{"name":"C\u00e1tedra y Servicio de Reproducci\u00f3n Animal Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata Argentina"},{"name":"CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MC","family":"Stornelli","sequence":"additional","affiliation":[{"name":"C\u00e1tedra y Servicio de Reproducci\u00f3n Animal Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RL","family":"de la Sota","sequence":"additional","affiliation":[{"name":"C\u00e1tedra y Servicio de Reproducci\u00f3n Animal Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata Argentina"},{"name":"CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Stornelli","sequence":"additional","affiliation":[{"name":"C\u00e1tedra y Servicio de Reproducci\u00f3n Animal Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1102","article-title":"The cystic hyperplasia\u2010pyometra complex in the bitch","volume":"70","author":"Dow C.","year":"1958","journal-title":"Veterinary Record"},{"key":"e_1_2_8_3_1","first-page":"445","volume-title":"Endocrinolog\u00eda y reproducci\u00f3n en perros y gatos","author":"Feldman C. 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