{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:42:10Z","timestamp":1761709330941,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T00:00:00Z","timestamp":1496534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","doi-asserted-by":"publisher","award":["573899\/2008\u20108"],"award-info":[{"award-number":["573899\/2008\u20108"]}],"id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>Puberty is a stage of sexual development determined by the interaction of environmental factors and genetic mechanisms. Among them, thyroid function plays a key role in sexual development and spermatogenic function and is under the control of several genes, including the well\u2010described thyroglobulin gene (<jats:italic><jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content><\/jats:italic>). Previous reports have shown genetic association between thyroid function and selected single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in taurine cattle. Therefore, the identification of genetic mechanisms involved in the regulation of this trait can assist with the selection for early pubertal bulls, thus improving genetic progress in livestock breeding. The aim of this study was to validate the association between <jats:italic><jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content><\/jats:italic> <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and age at puberty in zebuine bulls. Three <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s (rs110406764, rs109662686, rs109057985) were genotyped in 159 Guzerat animals using <jats:styled-content style=\"fixed-case\">SEQUENOM<\/jats:styled-content> technology. Results showed a significant association (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05) between the studied <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and puberty age, in agreement with our previous reports in a taurine breed. Interestingly, allele frequencies were different from those already reported, being <jats:styled-content style=\"fixed-case\">GAT<\/jats:styled-content> the most favourable allele for age at puberty in Guzerat (94.4\u00a0days lower). Overall, our findings corroborate previous reports and reinforce the importance of genetic influence in the regulation of sexual development and puberty through a thyroid pathway in zebuine cattle.<\/jats:p>","DOI":"10.1111\/rda.12989","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T04:02:41Z","timestamp":1496635361000},"page":"911-913","source":"Crossref","is-referenced-by-count":7,"title":["Bovine thyroglobulin gene polymorphisms and their association with sexual precocity in Guzerat bulls"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-0607","authenticated-orcid":false,"given":"ME","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"IGEVET \u2013 Instituto de Gen\u00e9tica Veterinaria \u201cIng. Fernando N. 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Fernando N. Dulout\u201d (UNLP\u2010CONICET LA PLATA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Cunha Cardoso","sequence":"additional","affiliation":[{"name":"Departamento de Zootecnia Universidade Federal de Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Giovambattista","sequence":"additional","affiliation":[{"name":"IGEVET \u2013 Instituto de Gen\u00e9tica Veterinaria \u201cIng. Fernando N. Dulout\u201d (UNLP\u2010CONICET LA PLATA) Facultad de Ciencias Veterinarias Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JP","family":"Liron","sequence":"additional","affiliation":[{"name":"IGEVET \u2013 Instituto de Gen\u00e9tica Veterinaria \u201cIng. Fernando N. 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