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Mature CL were collected during the mid\u2010luteal phase (days 30\u201345) from treated and control bitches. Transcript levels of several factors were determined: estrogen receptors (<jats:italic>ESR1\/ER<\/jats:italic>\u03b1, <jats:italic>ESR2\/ER<\/jats:italic>\u03b2<jats:italic>)<\/jats:italic>, progesterone (P4)\u2010receptor (<jats:italic>PGR<\/jats:italic>), prolactin receptor (<jats:italic>PRLR<\/jats:italic>), PGE2\u2010synthase (<jats:italic>PTGES<\/jats:italic>) and PGE2 receptors (<jats:italic>PTGER2\/EP2<\/jats:italic>,<jats:italic> PTGER4\/EP4<\/jats:italic>), vascular endothelial growth factor (<jats:italic>VEGFA<\/jats:italic>) and VEGF receptors (<jats:italic>VEGFR1<\/jats:italic> and <jats:italic>VEGFR2<\/jats:italic>), cyclooxygenase 2 (<jats:italic>COX2\/PTGS2<\/jats:italic>), steroidogenic acute regulatory protein (<jats:italic>STAR<\/jats:italic>) and 3\u03b2\u2010hydroxysteroid dehydrogenase (3\u03b2HSD). Additionally, levels of Kisspeptin 1 (<jats:italic>Kiss1<\/jats:italic>) and its receptor (<jats:italic>KISS1\u2010R<\/jats:italic>) were evaluated. Although generally low, <jats:italic>GnRH\u2010R<\/jats:italic> expression was time dependent and was elevated during early dioestrus, with a significant decrease towards luteal regression. In deslorelin\u2010treated and control dogs, its expression was either low or frequently below the detection limit. <jats:italic>EP2<\/jats:italic> and <jats:italic>VEGFR1<\/jats:italic> were higher in the treated group, which could be caused by a feedback mechanism after long\u2010term suppression of reproductive activity. Despite large individual variations, 3\u03b2HSD was higher in the deslorelin\u2010treated group. This, along with unchanged <jats:italic>STAR<\/jats:italic> expression, was apparently not mirrored in increased luteal functionality, because similar P4 levels were detected in both groups. Finally, the deslorelin\u2010mediated long\u2010term delay of puberty does not have negative carry\u2010over effects on subsequent ovarian functionality in bitches.<\/jats:p>","DOI":"10.1111\/rda.13038","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T05:42:40Z","timestamp":1506750160000},"page":"1104-1112","source":"Crossref","is-referenced-by-count":10,"title":["Expression of GnRH receptor in the canine corpus luteum, and luteal function following deslorelin acetate\u2010induced puberty delay"],"prefix":"10.1111","volume":"52","author":[{"given":"D","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine University of Kafkas  Kars Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7490-5836","authenticated-orcid":false,"given":"A","family":"Gram","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MP","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Sch\u00e4fer\u2010Somi","sequence":"additional","affiliation":[{"name":"Platform for Artificial Insemination and Embryo Transfer Vetmeduni Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Veterinary Medicine University of Kafkas  Kars Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Boos","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Institute of Veterinary Anatomy University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Veterinary Faculty Near East University  Nicosia North Cyprus Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.01.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000525"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.02.021"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20898"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06677.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1147"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/282090a0"},{"key":"e_1_2_8_9_1","first-page":"3","article-title":"Biology and endocrinology of ovulation, pregnancy and parturition in the dog","volume":"39","author":"Concannon P. 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