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The BCS<\/jats:styled-content>s of twenty non\u2010pregnant, anoestrous mares were determined prior to euthanasia, and tissue samples were collected from the liver, kidney, adrenal gland, ovary and endometrium. Cytochrome P450 1A (CYP<\/jats:styled-content>1A), 2C (CYP<\/jats:styled-content>2C), 3A (CYP<\/jats:styled-content>3A) and uridine 5\u2032\u2010diphospho\u2010glucuronosyltransferase (UGT<\/jats:styled-content>) activities were determined using luminogenic substrates. The MIXED<\/jats:styled-content> procedure of SAS<\/jats:styled-content> was used to test the effect of BCS<\/jats:styled-content> on enzyme activity and differences between tissues. Activity of CYP<\/jats:styled-content>1A in adrenals was increased (p\u00a0<\/jats:italic>\u2264\u00a0<\/jats:italic>.05) in BCS<\/jats:styled-content> 5 versus BCS<\/jats:styled-content>s 4 and 6. Activity of CYP<\/jats:styled-content>1A in the liver was increased (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.05) in BCS<\/jats:styled-content> 4 versus BCS<\/jats:styled-content>s 5 and 6. Activity of CYP<\/jats:styled-content>1A was 100\u2010fold greater (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001) in the liver than in the adrenal, ovary and kidney. Activity of CYP<\/jats:styled-content>2C was 100\u2010fold greater (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001) in the liver than in the adrenal, ovary and endometrium. Activity of CYP<\/jats:styled-content>3A was only detectable in the liver. Activity of UGT<\/jats:styled-content> in the kidney was decreased (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.02) in BCS<\/jats:styled-content> 4 versus BCS<\/jats:styled-content>s 5 and 6. Activity of UGT<\/jats:styled-content> was threefold greater (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001) in the liver than in the kidney, whereas activity of UGT<\/jats:styled-content> was ninefold greater (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001) in the kidney than in the ovary and endometrium. In general, BCS<\/jats:styled-content> did not alter the activity of steroid\u2010 and eicosanoid\u2010metabolizing enzymes in horses. However, tissue differences in these enzymes indicated abundant hepatic metabolism in horses, which is similar to other livestock species.<\/jats:p>","DOI":"10.1111\/rda.13104","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T04:18:45Z","timestamp":1510201125000},"page":"296-303","source":"Crossref","is-referenced-by-count":1,"title":["Effects of body condition score (BCS<\/scp>) on steroid\u2010 and eicosanoid\u2010metabolizing enzyme activity in various mare tissues during winter anoestrus"],"prefix":"10.1111","volume":"53","author":[{"given":"MPT","family":"Owen","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences Mississippi State University Mississippi State MS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EN","family":"Ferjak","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences Mississippi State University Mississippi State MS 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