{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:17:18Z","timestamp":1791933438411,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Contents<\/jats:title>\n                  <jats:p>\n                    Increased concentrations of Anti\u2010Muellerian hormone (\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    ) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    analysis. Ovaries were submitted for histopathological examination. Fourteen bitches showed normal ovaries. These bitches had\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    values between 0.12 and 0.99\u00a0ng\/ml. In 20 bitches ovarian cysts i.e., follicular cysts (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08), corpora lutea cysts (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a07), subsurface cysts (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05) were diagnosed. These dogs had\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    values of 0.11\u20132.09\u00a0ng\/ml. Bitches with small luteinized follicular cysts had slightly higher\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    values than those without ovarian alteration. In 29 cases ovarian neoplasms i.e., granulosa cell tumour (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a09), epithelial tumours (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a016), dysgerminomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a03) and one sarcoma were identified. Anti\u2010Muellerian hormone values of bitches with an ovarian neoplasm except granulosa cell tumour ranged from 0.18 to 1.18\u00a0ng\/ml. The\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    values of bitches with granulosa cell tumour ranged from 1.12 to \u226423\u00a0ng\/ml and were significantly higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05) than in all of the other bitches. The cut\u2010off of 0.99\u00a0ng\/ml gave a sensitivity of 100% and a specificity of 94.44% to diagnose granulosa cell tumour. In conclusion, markedly elevated\n                    <jats:styled-content style=\"fixed-case\">AMH<\/jats:styled-content>\n                    concentrations in bitches are indicative for a granulosa cell tumour. However, negative testing does not rule out the existence of small one. Differentiation of\n                    <jats:styled-content style=\"fixed-case\">GCT<\/jats:styled-content>\n                    from luteinized follicular cysts may especially be difficult.\n                  <\/jats:p>","DOI":"10.1111\/rda.13171","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T20:47:11Z","timestamp":1522442831000},"page":"784-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anti\u2010Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3570-6620","authenticated-orcid":false,"given":"B","family":"Walter","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic of Small Animal Surgery and Reproduction at the Centre for Clinical Veterinary Medicine Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Coelfen","sequence":"additional","affiliation":[{"name":"Laboklin GmbH &amp; Co.KG  Bad Kissingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Laboklin GmbH &amp; Co.KG  Bad Kissingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Reese","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Chair of Anatomy, Histology and Embryology Department of Veterinary Sciences Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Meyer\u2010Lindenberg","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Clinic of Small Animal Surgery and Reproduction at the Centre for Clinical Veterinary Medicine Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Aupperle\u2010Lellbach","sequence":"additional","affiliation":[{"name":"Laboklin GmbH &amp; Co.KG  Bad Kissingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.69.1033"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12781"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2012.00594.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.05.059"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2011.00385.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1024\/0036-7281\/a000510"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.06.031"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90783-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1998.tb00345.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-1742(60)80005-7"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2013.07.022"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.2010.00234.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3336"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(78)90041-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12822"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0487-5"},{"key":"e_1_2_9_18_1","first-page":"193","volume-title":"Canine and feline theriogenology","author":"Johnston S. 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