{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:10:16Z","timestamp":1784592616485,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T00:00:00Z","timestamp":1523404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Procad NF 157\/2010"],"award-info":[{"award-number":["Procad NF 157\/2010"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>To assess the effect of the angiotensin\u2010converting enzyme (<jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content>) inhibition on the efficiency of the fixed\u2010time artificial insemination (<jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content>), 69 goats were divided randomly into two groups: enalapril (<jats:italic>n<\/jats:italic>\u00a0=\u00a035) and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a034). In the experiment, all animals underwent the protocol of fixed\u2010time artificial insemination for 12\u00a0days. Enalapril group received enalapril maleate dissolved in saline (Enalapril, Lab Teuto Ltda) subcutaneously at the following doses: 0.2\u00a0mg\/kg\/day in D0\u2010D2; 0.3\u00a0mg\/kg\/day in D3\u2010D6 and 0.4\u00a0mg\/kg\/day in D7\u2010D11. The control group received the corresponding volume of 0.9% saline solution. We performed a single insemination 36\u00a0hr after sponge removal using frozen semen from two adult male goats with recognized fertility. The ultrasound pregnancy diagnosis was 30\u00a0days after the artificial insemination (<jats:styled-content style=\"fixed-case\">AI<\/jats:styled-content>). There was significant increase in pregnancy rates and twinning as well as a decrease in foetal loss in animals receiving enalapril (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). The use of <jats:styled-content style=\"fixed-case\">ACE<\/jats:styled-content> inhibitors during the <jats:styled-content style=\"fixed-case\">TAI<\/jats:styled-content> protocol was shown to be a promising alternative to increase the efficiency of such reproductive biotechnology.<\/jats:p>","DOI":"10.1111\/rda.13180","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T11:26:30Z","timestamp":1523445990000},"page":"1006-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>ACE<\/scp> inhibition in goats under fixed\u2010time artificial insemination protocol increases the pregnancy rate and twin births"],"prefix":"10.1111","volume":"53","author":[{"given":"VP","family":"Fernandes Neto","sequence":"first","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MNN","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AS","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AS","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LCS","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MCS","family":"Muratori","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1966-913X","authenticated-orcid":false,"given":"APR","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed  Teresina Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(03)00214-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02118626"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2004000800017"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220787"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12384"},{"key":"e_1_2_8_7_1","first-page":"243","article-title":"Sistema Renina Angiotensina Ovariano","volume":"34","author":"Feitosa L. C. S.","year":"2010","journal-title":"Revista Brasileira de Reprodu\u00e7\u00e3o Animal"},{"key":"e_1_2_8_8_1","first-page":"25","article-title":"Controle do estro e da ovula\u00e7\u00e3o em bovinos e ovinos","author":"Moraes J. C. F.","year":"2008","journal-title":"Biot\u00e9cnicas Aplicadas \u00e0 Reprodu\u00e7\u00e3o Animal"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0531.2002.00335.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2010.01.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod38.3.695"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2011.058453"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.13180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.13180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T17:19:11Z","timestamp":1694971151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.13180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,11]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/rda.13180"],"URL":"https:\/\/doi.org\/10.1111\/rda.13180","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,11]]},"assertion":[{"value":"2017-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}