{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:02:08Z","timestamp":1785600128075,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K07684"],"award-info":[{"award-number":["15K07684"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23580363"],"award-info":[{"award-number":["23580363"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>The relationship between vaginal discharge characteristics and metabolic status has been studied in postpartum dairy cows. Vaginal discharges at 2\u20136\u00a0weeks postpartum were scored weekly on a 1 (clear) to 5 (purulent material with stench) scale using the Metricheck device and classified into three groups as follows: Endometritis group (<jats:italic>n<\/jats:italic>\u00a0=\u00a019), greater than or equal to score 4 until 3\u00a0weeks postpartum; Delayed involution group (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), score 2 or 3 after having score 1; Healthy group (<jats:italic>n<\/jats:italic>\u00a0=\u00a023), cows except those belonging to the Delayed involution and Endometritis groups. The uterus and cervix were assessed using ultrasonography. Blood samples were collected twice weekly from 1 to 6\u00a0weeks postpartum from all cows and were additionally obtained for 13,14\u2010dihydro\u201015\u2010keto\u2010prostaglandin F2\u03b1 (PGFM) measurements from multiparous cows. Cows with delayed involution had delayed onset of luteal activity (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05) and higher serum urea nitrogen (BUN) concentrations (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.01) than healthy animals. Cows with endometritis had more peripartum diseases (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05), lower milk yield (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05), longer cervix diameter (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.05), and lower serum albumin (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.01), total cholesterol (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.01), and magnesium (<jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>0.01) concentrations, and higher aspartate aminotransferase levels (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) than healthy cows. Plasma PGFM concentrations tended to be higher in the Delayed involution group (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.083) and lower in the Endometritis group (<jats:italic>p\u00a0=\u00a0<\/jats:italic>0.085) than in the Healthy group. In summary, delayed involution was shown to be associated with higher BUN concentration, and endometritis may have been caused by peripartum diseases and hepatic dysfunction.<\/jats:p>","DOI":"10.1111\/rda.13255","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T08:18:48Z","timestamp":1532679528000},"page":"1396-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relationship of vaginal discharge characteristics evaluated by Metricheck device to metabolic status in postpartum dairy cows"],"prefix":"10.1111","volume":"53","author":[{"given":"Chiho","family":"Kawashima","sequence":"first","affiliation":[{"name":"Field Centre of Animal Science and Agriculture Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Suwanai","sequence":"additional","affiliation":[{"name":"Field Centre of Animal Science and Agriculture Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Honda","sequence":"additional","affiliation":[{"name":"Field Centre of Animal Science and Agriculture Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"},{"name":"United Graduate School of Agricultural Sciences Iwate University Morioka Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Teramura","sequence":"additional","affiliation":[{"name":"United Graduate School of Agricultural Sciences Iwate University Morioka Iwate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Kida","sequence":"additional","affiliation":[{"name":"Field Centre of Animal Science and Agriculture Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Hanada","sequence":"additional","affiliation":[{"name":"Department of Life and Food Sciences Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Life and Food Sciences Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4679-6564","authenticated-orcid":false,"given":"Motozumi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.6.1419"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.12.005"},{"key":"e_1_2_8_4_1","first-page":"411","article-title":"Effects of energy balance on follicular development and first ovulation in postpartum dairy cows","volume":"54","author":"Beam S. 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