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The oestrous cycle is also associated with significant changes in plasma follicle\u2010stimulating hormone (FSH), whose effects are mediated through its receptor (FSHR). Reports showed that in many mammals, FSHR was expressed in gonadal and extragonadal tissues including cervix, female reproductive tract, and pituitary gland. Follicle\u2010stimulating hormone (FSH) signals through endothelial FSHR directly stimulate angiogenesis and involved in the timing of birth in human, and the presence of FSHR in the placenta is essential for normal pregnancy in mice. But little is known about FSHR expression in the yak uterus. The main objective of the present study was to determine the expression and localization of FSHR in the yak uterus during different phases of the oestrous cycle. Results showed that FSHR protein was localized in the surface and glandular epithelial cells, stroma cells, myometrial smooth muscle cells and blood vessel endothelial cells. The expression of FSHR protein peaked at oestrus, significantly decreased at dioestrus (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and increased again at proestrus. FSHR mRNA was highly expressed at both proestrus and oestrus, and decreased at metestrus with the lowest values at dioestrus (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In conclusion, FSHR expression in the yak uterus changed with the stage of the oestrous cycle suggesting that FSHR plays an essential role in regulating the endometrial and myometrial functions during the oestrus cycle in the yak.<\/jats:p>","DOI":"10.1111\/rda.13313","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T10:45:16Z","timestamp":1534589116000},"page":"1539-1545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Expression and localization of follicle\u2010stimulating hormone receptor in the yak uterus during different stages of the oestrous cycle"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8683-5417","authenticated-orcid":false,"given":"Ayimuguli","family":"Abudureyimu","sequence":"first","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"},{"name":"College of Veterinary Medicine Gansu Agricultural University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cai","sequence":"additional","affiliation":[{"name":"Experimental Center of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengdong","family":"Huo","sequence":"additional","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ren","sequence":"additional","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxin","family":"Zang","sequence":"additional","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutian","family":"Yang","sequence":"additional","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongren","family":"Ma","sequence":"additional","affiliation":[{"name":"Life Science and Engineering College of Northwest University for Nationalities Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Gansu Agricultural University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9404-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90275-9"},{"key":"e_1_2_9_4_1","first-page":"2355","article-title":"Different expression of estrogen receptor \u03b1 and progesterone receptor in yak uterus during the estrous cycle","volume":"44","author":"Ayimuguli A.","year":"2011","journal-title":"Scientia Agricultura Sinica"},{"key":"e_1_2_9_5_1","first-page":"2S24","article-title":"Role of FSH and LH in follicle development","volume":"35","author":"Baird D.","year":"2006","journal-title":"Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.09.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.07.1391"},{"key":"e_1_2_9_8_1","first-page":"1213","article-title":"Observation of the histological structure of the yak (Bos grunniens) uterus during estrous cycle","volume":"41","author":"Duan Y. 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