{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:21:27Z","timestamp":1785270087922,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,11]],"date-time":"2018-11-11T00:00:00Z","timestamp":1541894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008418","name":"Guru Angad Dev Veterinary and Animal Sciences University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Contents<\/jats:title><jats:p>This study examined the effect of single IU administration of cephapirin on clinical recovery, clearance of uterine bacteria and reproductive performance of postpartum buffaloes with subclinical endometritis (SCE). Buffaloes (<jats:italic>n<\/jats:italic>\u00a0=\u00a086) at 35\u00a0days postpartum (DPP) with &gt;10% polymorphonuclear (PMN) cells in endometrial cytosmears were designated as positive (SCEP,<jats:italic>n<\/jats:italic>\u00a0=\u00a029), and buffaloes with \u226410% PMN cell were designated as negative (SCEN,<jats:italic>n<\/jats:italic>\u00a0=\u00a057) for SCE. Out of 29 positive buffaloes, 15 were administered a single intrauterine dose of cephapirin benzathine on 40 DPP (SCEP\u2010CB), while the remaining 14 animals were kept as untreated control (SCEP\u2010C). All animals were observed regularly for oestrous signs and were again subjected to cytobrush sampling on the first postpartum (FPP) oestrus. Buffaloes positive for SCE at 35 DPP were later considered \u201crecovered\u201d if their PMN cells dropped to \u22645% on the FPP oestrus. Presence of<jats:italic>Escherichia coli, Arcanobacterium pyogenes<\/jats:italic>and<jats:italic>Fusobacterium necrophorum<\/jats:italic>in uterus was detected based upon PCR amplification of genes related to bacteria\u2010specific virulence factors. A total of 66.7% of SCEP\u2010CB group buffaloes recovered as compared to 28.6% in SCEP\u2010C (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a04.21;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Rate of bacterial clearance did not differ between treated (38.5%) and untreated buffaloes (8.3%) (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a01.67;<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). The median days to first service did not differ significantly (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05) among the three groups, whereas cephapirin administration reduced (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) the days open by 14\u00a0days in SCEP\u2010CB compared to SCEP\u2010C buffaloes. SCEP\u2010CB buffaloes were as likely to conceive as SCEN, whereas SCEP\u2010C had 0.28 hazard ratio for pregnancy. In conclusion, a single treatment with cephapirin benzathine at 40 DPP improved the reproductive performance of buffaloes with subclinical endometritis.<\/jats:p>","DOI":"10.1111\/rda.13362","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T14:20:41Z","timestamp":1539699641000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical efficacy of intrauterine cephapirin benzathine administration on clearance of uterine bacteria and subclinical endometritis in postpartum buffaloes"],"prefix":"10.1111","volume":"54","author":[{"given":"Dawoud A.","family":"Nehru","sequence":"first","affiliation":[{"name":"Guru Angad Dev veterinary and Animal Sciences University Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurcharan. S.","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Guru Angad Dev veterinary and Animal Sciences University Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-891X","authenticated-orcid":false,"given":"Mustafa. H.","family":"Jan","sequence":"additional","affiliation":[{"name":"ICAR\u2010Central Institute for Research on Buffaloes, sub\u2010Campus Nabha Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-7339","authenticated-orcid":false,"given":"Ranjna S.","family":"Cheema","sequence":"additional","affiliation":[{"name":"Guru Angad Dev veterinary and Animal Sciences University Ludhiana Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICAR\u2010Central Institute for Research on Buffaloes, sub\u2010Campus Nabha Patiala Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0026261710040168"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.07.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.11.034"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:VERC.0000014130.53246.fc"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2014.06.021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2015.02.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-3356"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-014-0661-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.12.005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.092718"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5958\/0973-970X.2015.00076.0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7450"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(00)00410-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(95)00123-P"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2011.08.033"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4781"},{"key":"e_1_2_9_18_1","first-page":"1","article-title":"Efficiency of uterine fluid cytology in the diagnosis of subclinical endometritis in the water buffalo (Bubalus bubalis)","volume":"11","author":"Gahlot S. 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