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In the present study, we have investigated whether dietary L\u2010arginine supplementation stimulates early conceptus growth in mares. Warmblood mares with singleton pregnancies received either an arginine\u2010supplemented diet (approximately 0.0125% of body weight, <jats:italic>n<\/jats:italic>\u00a0=\u00a012) or a control diet (<jats:italic>n<\/jats:italic>\u00a0=\u00a011) from days 15 to 45 after ovulation. Diameter of the embryonic vesicle (days 14, 17, 20 of pregnancy) and size of the embryo respective foetus (length and maximal diameter, days 25\u201345 of pregnancy at 5\u2010day intervals) were determined by transrectal ultrasound. At foaling, weight and size of the foal and the placenta were determined. Blood for determination of equine chorionic gonadotrophin (eCG) and progestin concentrations was collected repeatedly. Neither eCG nor progestin concentration in plasma of mares differed between groups at any time. No effects of arginine treatment on diameter of the embryonic vesicle between days 14 and 20 of pregnancy were detected. Diameter of the embryo\/foetus on days 40 to 45 of pregnancy strongly tended to be enhanced by arginine supplementation (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.06). Weight and size of neither the foal nor placenta at birth differed between groups. In conclusion, L\u2010arginine supplementation was without negative effects on early equine embryos and may support embryonic growth at the beginning of placentation.<\/jats:p>","DOI":"10.1111\/rda.13422","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T08:21:45Z","timestamp":1551255705000},"page":"772-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of dietary L\u2010arginine supplementation to early pregnant mares on conceptus diameter\u2014Preliminary findings"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8849-9189","authenticated-orcid":false,"given":"J\u00f6rg","family":"Aurich","sequence":"first","affiliation":[{"name":"Department of Small Animals and Horses, Obstetrics, Gynaecology and Andrology Vetmeduni Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"K\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Small Animals and Horses, Obstetrics, Gynaecology and Andrology Vetmeduni Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Wulf","sequence":"additional","affiliation":[{"name":"Graf Lehndorff Institute for Equine Science Vetmeduni Vienna Neustadt (Dosse) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7990-1201","authenticated-orcid":false,"given":"Christina","family":"Nagel","sequence":"additional","affiliation":[{"name":"Graf Lehndorff Institute for Equine Science Vetmeduni Vienna Neustadt (Dosse) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Beythien","sequence":"additional","affiliation":[{"name":"Graf Lehndorff Institute for Equine Science Vetmeduni Vienna Neustadt (Dosse) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Gautier","sequence":"additional","affiliation":[{"name":"Department of Small Animals and Horses, Obstetrics, Gynaecology and Andrology Vetmeduni Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Zentek","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition Free University Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-7362","authenticated-orcid":false,"given":"Christine","family":"Aurich","sequence":"additional","affiliation":[{"name":"Department of Small Animals and Horses, Artificial Insemination and Embryo Transfer Vetmeduni Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"445","article-title":"Effect of uterine inflammation and ultrasonically\u2010detected uterine pathology on fertility in the mare","volume":"35","author":"Adams G. 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