{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:11Z","timestamp":1787015891410,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Contents<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to compare the reproductive performance of cows affected by clinical endometritis (CE) following treatment with an intrauterine infusion of 50% dextrose solutions (DEX) and liquid paraffin (LP) as alternative therapies with routine treatments including PGF\n                    <jats:sub>2\u03b1<\/jats:sub>\n                    injection and intrauterine infusion of oxytetracycline (OTC). Moreover, the reproductive indices of cows treated with endometritis were compared with those of healthy ones. At postpartum reproductive tract examination (28\u201335 DIM) in one Iranian dairy farm, cows with CE without any selection were assigned to four groups: (a) OTC, a common treatment in Iran, was administered (5\u00a0g) to 396 cows, (b) PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 (PG) was injected to 496 cows, (c) dextrose solution (DEX): intrauterine infusion of 50% dextrose solution (200\u00a0ml) was done in 427 cows, and (d) liquid paraffin (LP) was administered (100\u00a0ml) to 423 cows via intrauterine route. We further assigned 2,233 clinically healthy cows to the control group. The incidence of endometritis was 41.6% in this study. Based on the results of reproductive indices including median days to first AI, days open (DO), first service conception rate, conception rate in 2nd and 3rd services, conception rate in all three services, pregnancy rate\u00a0&lt;\u00a0100\u00a0days and pregnancy rate\u00a0&lt;\u00a0200\u00a0days, except for median days to first AI in other reproductive indexes, reproductive performance was significantly lower in LP group compared with the healthy cows and other treatment groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Except for the first service conception rate and proportion of cows pregnant before 100\u00a0days in milk (DIM), there existed no significant difference between the DEX group and the control as far as reproductive performance is concerned (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u2265\u00a00.05). The first service conception rate was recognizably lower in DEX group compared with OTC and PG (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). In conclusion, the use of a non\u2010antibiotic special solution of dextrose 50% is a good alternative to antibiotic agents concerning the treatment of CE in dairy cows.\n                  <\/jats:p>","DOI":"10.1111\/rda.13424","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T20:02:25Z","timestamp":1551297745000},"page":"762-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of hypertonic dextrose and paraffin solution as non\u2010antibiotic treatments of clinical endometritis on reproductive performance of high producing dairy cows"],"prefix":"10.1111","volume":"54","author":[{"given":"Mohammad Rahim","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4264-2485","authenticated-orcid":false,"given":"Meysam","family":"Makki","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Clinical Sciences Shahid Chamran University Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolah","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid Reza","family":"Gheisari","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Veterinary Medicine Shiraz University Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"155","article-title":"A controlled model of 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