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In this regard, we studied the immunomodulatory effect of curcumin 30\u00a0\u00b5M, on lipopolysaccharide\u2010 (LPS) and\/or flagellin (100\u00a0ng\/ml each)\u2010induced prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) and proinflammatory cytokines (PIC) using primary bubaline endometrial stromal cells. After 24\u00a0hr treatment, the supernatant was assayed for PGE<jats:sub>2<\/jats:sub> while cells were used for relative quantification of cytokines like IL\u20101\u03b2, IL\u20106, IL\u20108 and TNF \u03b1 transcripts using a control group as calibrator. LPS was found to possess potent stimulatory effect on PGE<jats:sub>2<\/jats:sub> production, whereas the flagellin was not as potent as LPS in stimulating the PGE<jats:sub>2<\/jats:sub> production either per se or in combination with LPS. LPS markedly up\u2010regulated the transcripts of IL\u20108 and IL\u20106 as compared to IL\u20101\u03b2 and TNF \u03b1 in the bubaline endometrial stromal cells. Except for IL\u20108, flagellin did not up\u2010regulate other PICs. There was no additive effect between LPS and flagellin on the up\u2010regulation of inflammatory cytokines. Curcumin inhibited the LPS\u2010induced up\u2010regulation of PIC with strong down\u2010regulation of IL\u20108. The inhibitory effects of curcumin on the inflammatory mediators suggest a potential in the treatment of bovine endometritis.<\/jats:p>","DOI":"10.1111\/rda.13435","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T22:58:20Z","timestamp":1555023500000},"page":"917-923","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunomodulatory effect of curcumin on lipopolysaccharide\u2010 and\/or flagellin\u2010induced production of prostaglandin E2 and relative expression of proinflammatory cytokines in the primary bubaline endometrial stromal cells"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9782-0050","authenticated-orcid":false,"given":"Rouf","family":"Rashid Dar","sequence":"first","affiliation":[{"name":"Division of Animal Reproduction Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaz","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Animal Reproduction Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh Firdous","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Animal Genetics and Breeding Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar Singh","sequence":"additional","affiliation":[{"name":"Division of Animal Reproduction Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-9216","authenticated-orcid":false,"given":"Manas Kumar","family":"Patra","sequence":"additional","affiliation":[{"name":"Livestock Production and Management Section Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8578-2325","authenticated-orcid":false,"given":"Manjit","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Division of Animal Genetics and Breeding Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Animal Reproduction Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Division of Animal Reproduction Indian Veterinary Research Institute Bareilly India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0404"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-014-9594-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12817"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.060"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202493"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2017-0067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12764"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1320"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2016.12.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.01.006"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.12287"},{"key":"e_1_2_9_13_1","first-page":"469","article-title":"Curcumin attenuates the expression of IL\u20101\u00df, IL\u20106, and TNF\u2010\u03b1 as well as cyclin E in TNF\u2010\u03b1\u2010treated HaCaT cells: NF\u2010\u03baB and MAPKs as potential upstream targets","volume":"19","author":"Cho J. 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