{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:56:48Z","timestamp":1747187808359,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T00:00:00Z","timestamp":1565049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is evidence that supplementing methionine has positive effects on uterine environment, oocyte quality and embryo development in cattle. Thus, the objective of this study was to evaluate reproductive traits of cows supplemented with rumen\u2010protected methionine (RPM) during early to mid\u2010lactation in comparison with an untreated control group (CON). An additional focus was on the effect of puerperal diseases on reproductive performance parameters in RPM\u2010supplemented group MET and in CON. A total of 1,709 multiparous Holstein\u2010Friesian cows were enrolled in this field trial conducted on a commercial dairy farm in Slovakia. Cows were allocated at approximately 12\u00a0days post\u2010partum (dpp) to either CON or MET, the latter supplemented with 25.0\u00a0g\u201327.2\u00a0g RPM per cow per day incorporated into the total mixed ration (TMR) until leaving the study pen at approximately 140\u00a0dpp. The amount of RPM was calculated based on individual feed ingredients analysis and adjusted during the study period when TMR changed. Cows were monitored during the post\u2010partum period by vaginal examination (day 5\u00a0pp), measuring of beta\u2010hydroxybutyrate in blood (3, 5, and 8\u00a0dpp) and by vaginal examination, uterine cytology and measuring of back fat thickness by ultrasound (all at 31\u00a0\u00b1\u00a03\u00a0dpp).<\/jats:p><jats:p>Compared with CON, cows supplemented with RPM did not show better reproduction performance parameters (first service submission rate, days to first service, conception risk, days open 140). Results from binary logistic regression model for the risk of conception showed that metritis had a significant effect, but the supplementation of methionine had not. Results of Cox regression analysis for the odds of conception within 140\u00a0dpp revealed only metritis and clinical endometritis as significant factors. In conclusion, supplementation of RPM had no beneficial effect on reproductive performance in this study farm compared with an untreated control group.<\/jats:p>","DOI":"10.1111\/rda.13509","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T16:40:03Z","timestamp":1563036003000},"page":"1265-1273","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Supplementing rumen\u2010protected methionine to lactating multiparous dairy cows did not improve reproductive performance"],"prefix":"10.1111","volume":"54","author":[{"given":"David","family":"S\u00fcss","sequence":"first","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7893-6050","authenticated-orcid":false,"given":"Michael","family":"Iwersen","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Schweinzer","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Gusterer","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kanz","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Krieger","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2361-721X","authenticated-orcid":false,"given":"Harald","family":"Pothmann","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Wagener","sequence":"additional","affiliation":[{"name":"Clinical Unit for Herd Health Management in Ruminants, Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hoelker","sequence":"additional","affiliation":[{"name":"Research Station Frankenforst, Faculty of Agriculture University of Bonn K\u00f6nigswinter Germany"},{"name":"Institute of Animal Science, Animal breeding and Husbandry University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawit","family":"Tesfaye","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Animal breeding and Husbandry University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Schellander","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Animal breeding and Husbandry University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Helmbrecht","sequence":"additional","affiliation":[{"name":"Evonik Nutrition &amp; 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