{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:07:34Z","timestamp":1790633254120,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to examine the impact of a bovine respiratory disease complex (BRDC) vaccine with a temperature\u2010sensitive\u00a0modified live vaccine (MLV) infectious bovine rhinotracheitis (IBR) component on oestrous cycle parameters and the follicular pool. Twenty\u2010four Holstein heifers (12.4\u00a0\u00b1\u00a00.5\u00a0months) previously calfhood vaccinated with an IBR MLV component were enrolled in two replicates (Spring; <jats:italic>n<\/jats:italic>\u00a0=\u00a010 and Fall; <jats:italic>n<\/jats:italic>\u00a0=\u00a014) and were blocked by pre\u2010vaccination bovine viral diarrhoea (BVD) serum neutralizing (SN) titres. Upon enrolment, heifers were oestrous synchronized with sampling beginning at detected oestrus. At their second heat, heifers were vaccinated with a BRDC calfhood vaccine with a MLV (MLV; <jats:italic>n<\/jats:italic>\u00a0=\u00a012) or killed (K; <jats:italic>n<\/jats:italic>\u00a0=\u00a012) IBR component and sampled for two additional cycles. Serum samples for oestrogen (E2) and progesterone (P4) as well as ultrasound data of ovarian structures were collected every other day. Serum samples for anti\u2010M\u00fcllerian hormone (AMH) were collected at oestrus and mid\u2010cycle for each cycle, and serum for titres was collected prior to and following vaccination. Data were analysed with the PROC MIXED and GLM procedures of SAS. There was no difference in pre\u2010 or post\u2010vaccination titres between MLV and K heifers (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.5). Vaccination had no impact on P4 concentrations, P4 area under the curve, luteal tissue area, peak E2 production or oestrous cycle length (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). Cycle number did impact AMH concentration (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). In MLV heifers, AMH concentration was highest in cycle 1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) while cycles 2 and 3 did not differ (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). This was also true for the K heifers in the Fall replicate (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Within cycle 2, AMH concentrations were numerically lower between vaccine types (K\u00a0=\u00a0308.22\u00a0\u00b1\u00a033.3\u00a0pg\/ml, MLV\u00a0=\u00a0181.13\u00a0\u00b1\u00a032.9\u00a0pg\/ml; <jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). Although no differences were seen in overall cycle parameters, differences in AMH concentrations may indicate a reduction of the follicular pool following vaccination and\u00a0requires further investigation.<\/jats:p>","DOI":"10.1111\/rda.13554","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T17:19:10Z","timestamp":1566667150000},"page":"1470-1476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of a bovine respiratory disease vaccine with a temperature\u2010sensitive\u00a0modified live or killed infectious bovine rhinotracheitis component on oestrous cycle parameters and anti\u2010M\u00fcllerian hormone concentration in nulliparous heifers"],"prefix":"10.1111","volume":"54","author":[{"given":"Caitlin Lark","family":"Widener","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Science University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Science University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla J.","family":"Alward","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Science University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-4641","authenticated-orcid":false,"given":"Jillian F.","family":"Bohlen","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Science University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.04.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90783-X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093-691X(90)90071-Z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.071670"},{"key":"e_1_2_10_6_1","first-page":"556","article-title":"A diagnostic survey of bovine abortion and still birth in the northern plains states","volume":"162","author":"Kirkbride C. A.","year":"1973","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0810301"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2008.11.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1785"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2012.10.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.072157"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2008.11.009"},{"issue":"7","key":"e_1_2_10_13_1","first-page":"33","article-title":"Absence of ovarian lesions in IBR seropositive heifers subsequently vaccinated with a modified live IBR virus vaccine","volume":"16","author":"Spire M. F.","year":"1996","journal-title":"Agri\u2010Practice"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-10-0327"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1135(85)90017-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-114-4-1315"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah015"},{"key":"e_1_2_10_18_1","volume-title":"Cattlemaster gold fp 5 l5 package insert","author":"Zoetis","year":"2015"}],"container-title":["Reproduction in Domestic Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Frda.13554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.13554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/rda.13554","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/rda.13554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T23:53:10Z","timestamp":1694217190000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/rda.13554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/rda.13554"],"URL":"https:\/\/doi.org\/10.1111\/rda.13554","archive":["Portico"],"relation":{},"ISSN":["0936-6768","1439-0531"],"issn-type":[{"value":"0936-6768","type":"print"},{"value":"1439-0531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"2019-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}