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In the VMH\/DMH, <jats:italic>PRLR<\/jats:italic> transcripts were detected only in non\u2010pregnant ewes. In the ARC, the abundances of <jats:italic>PRLR<\/jats:italic> mRNA were higher in pregnant sheep on days 30 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), 90 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and 120 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) than in non\u2010pregnant sheep. In contrast, the expression of <jats:italic>PRLR<\/jats:italic> mRNA in the ME was lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) in pregnant ewes at days 30 and 60 than in non\u2010pregnant ewes and was undetectable at later stages of gestation. In all studied stages of pregnancy except day 60, the abundance of PRLR mRNA was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) in the ARC than in the AP, while in non\u2010pregnant sheep, there were no differences (<jats:italic>p<\/jats:italic>\u00a0\u2265\u00a0.05) in the transcript levels between these two tissues. In non\u2010pregnant ewes, the abundance of <jats:italic>SOCS\u20103<\/jats:italic> mRNA in the AP was lower than that in any other studied tissue (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05\u2010<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). In conclusion, the observed changes in <jats:italic>PRLR<\/jats:italic> and <jats:italic>SOCS\u20103<\/jats:italic> mRNA abundance in the hypothalamus and AP during pregnancy may be important components of the mechanisms regulating the action of PRL in energy homeostasis and neuroendocrine interactions within the hypothalamic\u2013pituitary axis.<\/jats:p>","DOI":"10.1111\/rda.13576","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T20:48:10Z","timestamp":1571431690000},"page":"21-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy\u2010induced changes in the transcript levels of prolactin receptor and its suppressor in the ovine hypothalamus and 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