{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:16:36Z","timestamp":1786392996525,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T00:00:00Z","timestamp":1579996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous subclinical diseases in sheep occur in the periparturient period and involve inflammatory processes; therefore, determining markers, such as acute\u2010phase proteins (APPs), can allow an early diagnosis. Therefore, the objective of the present study was to assess changes in the plasma concentration of APPs and cortisol in clinically healthy ewes in the periparturient period for use in future studies. At the same time, haematological parameters were monitored. We showed that plasma APPs and cortisol concentrations were significantly higher in pregnant ewes than before insemination. A gradual increase in the SAA concentration was observed from the 14th day before to the day of parturition, while Hp was reduced from 2\u00a0weeks before up to 2\u00a0weeks after delivery. A significant increase in the Fb concentration was detected from the 14th day before to the 1st week after delivery. The cortisol concentration did not undergo significant changes in the periparturient period. We found an increase in the SAA and Fb concentrations and decrease in Hp in the periparturient period. The direction of the change in APPs of healthy ewes in the current study may be related to their distinct regulatory mechanisms during pregnancy. The APPs are usually altered during infection, inflammation, neoplasia, stress and trauma; therefore, knowing their reference values could help lead to an early diagnosis of subclinical forms of some diseases and pregnancy complications in ewes. The haematological analysis showed that ewes in late pregnancy and postpartum compared to dry period were under metabolic stress related to pregnancy and lactation.<\/jats:p>","DOI":"10.1111\/rda.13628","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T07:34:30Z","timestamp":1578555270000},"page":"393-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Acute\u2010phase proteins, cortisol and haematological parameters in ewes during the periparturient period"],"prefix":"10.1111","volume":"55","author":[{"given":"Monika","family":"Gregu\u0142a\u2010Kania","sequence":"first","affiliation":[{"name":"Institute of Animal Breeding and Biodiversity Conservation Faculty of Biology, Animal Sciences and Bioeconomy University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-5103","authenticated-orcid":false,"given":"Urszula","family":"Kosior\u2010Korzecka","sequence":"additional","affiliation":[{"name":"Sub\u2010Department of Pathophysiology Department of Preclinical Veterinary Sciences Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Patkowski","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Biodiversity Conservation Faculty of Biology, Animal Sciences and Bioeconomy University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Juszczuk\u2010Kubiak","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases with Clinic and Veterinary Research Centre and Center for Biomedical Research Faculty of Veterinary Medicine Warsaw University of Life Science\u2010SGGW Warsaw Poland"},{"name":"Laboratory of Genome and Transcriptome Sequencing Department of Molecular Biology Institute of Genetics and Animal Breeding Polish Academy of Sciences Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Plewik","sequence":"additional","affiliation":[{"name":"Sub\u2010Department of Pathophysiology Department of Preclinical Veterinary Sciences Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz Maria","family":"Gruszecki","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding and Biodiversity Conservation Faculty of Biology, Animal Sciences and Bioeconomy University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1995.9694521"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2460\/ajvr.1993.54.01.164","article-title":"Peripartum acute\u2010phase protein serum amyloid\u2010A concentration in plasma of cows and fetuses","volume":"54","author":"Alsemgeest S. 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