{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:52:14Z","timestamp":1778280734166,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["Grant No. 2016\/21\/N\/NZ9\/02301"],"award-info":[{"award-number":["Grant No. 2016\/21\/N\/NZ9\/02301"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In pigs, plasma prolactin concentration markedly changes during the oestrous cycle and the regulation of its secretion is very complex. The contribution of neurokinins in this process has not been sufficiently delineated. The aim of the study was to examine the effects of neurokinin A (NKA) on prolactin synthesis and secretion in cyclic gilts. The expression of NKA precursor (<jats:italic>Ppta<\/jats:italic>) and receptor (<jats:italic>Tacr2<\/jats:italic>) genes as well as NKA and TACR proteins content in the porcine pituitaries (days 2\u20133, 9\u201310, 12\u201313, 15\u201316 and 19\u201320 of the cycle) was determined. Furthermore, the in vitro influence of NKA on the expression of prolactin (<jats:italic>Prl<\/jats:italic>), dopamine receptor (<jats:italic>D2r<\/jats:italic>), TRH receptor (<jats:italic>Trhr<\/jats:italic>) genes and prolactin secretion by the porcine pituitary cells (days 9\u201310, 15\u201316 and 19\u201320 of the cycle) was assessed. The expression of <jats:italic>Ppta<\/jats:italic> and <jats:italic>Tacr2<\/jats:italic> as well as NKA and TACR proteins in the pituitary tissue has been changing throughout the oestrous cycle. NKA affected in vitro the expression of studied genes and prolactin secretion depending on the stage of the cycle, dose of NKA and\/or duration of the cell incubation. Altogether, the study indicates that NKA is engaged in the modulation of prolactin secretion in the pig during the oestrous cycle.<\/jats:p>","DOI":"10.1111\/rda.13659","type":"journal-article","created":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T10:15:55Z","timestamp":1582366555000},"page":"604-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of neurokinin A and its receptor in the regulation of prolactin secretion by the anterior pituitary of cyclic pigs"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-7465","authenticated-orcid":false,"given":"Wioleta","family":"Czelejewska","sequence":"first","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-130X","authenticated-orcid":false,"given":"Agata","family":"Zmijewska","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariusz","family":"Dziekonski","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw","family":"Okrasa","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,15]]},"reference":[{"issue":"10","key":"e_1_2_8_2_1","first-page":"1953","article-title":"Gross ovarian changes during estrous cycle of swine","volume":"29","author":"Akins E. 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