{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:15:30Z","timestamp":1782310530067,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aims of this study were to characterize the biochemical profile, the reproductive performance and to identify potential predictive biomarkers of disease state of dairy cows with hyperketonemia, lipomobilization and hypocalcemia raised in tropical conditions in southeastern Brazil. Dairy cows (n\u00a0=\u00a050) were divided into a group of healthy cows (n\u00a0=\u00a014), cows with lipomobilization (n\u00a0=\u00a014), cows with hypocalcemia (n\u00a0=\u00a011), and a group of cows with hyperketonemia (n\u00a0=\u00a011). Evaluation of body condition score (BCS), body weight (BW) and blood samples was performed on 21, 14, 7, 4 and 2\u00a0days before calving, parturition, 1, 7, 14, 21, 30, 45 and 60\u00a0days post\u2010partum and milk production was recorded on days 7, 14, 21, 30, 45 and 60 after parturition. Blood samples were assayed for aspartate aminotransferase (AST), gamma\u2010glutammyltransferase (GGT), albumin, total protein, globulin, fibrinogen, total cholesterol, triglyceride, urea and creatinine concentrations. The biochemical profile, BCS, BW, milk production and reproductive performance differed (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) among the groups. Our findings indicate changes in the biochemical profile of dairy cows with metabolic diseases and impaired production and fertility of dairy cows in this group. Variable importance in projection plots demonstrated that cholesterol, urea, total protein, albumin and fibrinogen in the serum were the strongest discriminators between cows with hypocalcemia and healthy cows; and AST, cholesterol, urea and triglycerides for cows with hyperketonemia and healthy cows; and cholesterol, urea, triglycerides, total protein and fibrinogen for lipomobilization and healthy cows, which might be useful as predictive biomarkers of the disease state.<\/jats:p>","DOI":"10.1111\/rda.13768","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T17:52:53Z","timestamp":1594144373000},"page":"1219-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of biochemical profile of dairy cows with metabolic diseases in tropical conditions"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-371X","authenticated-orcid":false,"given":"Renan Braga","family":"Paiano","sequence":"first","affiliation":[{"name":"Department of Animal Reproduction School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Anatomy of Domestic and Wild Animals School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-5720","authenticated-orcid":false,"given":"Daniela Becker","family":"Birgel","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-0096","authenticated-orcid":false,"given":"Jeannine","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Department of Food Engineering Faculty of Animal Science and Food Engineering University of S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-0549","authenticated-orcid":false,"given":"Eduardo Harry","family":"Birgel Junior","sequence":"additional","affiliation":[{"name":"Department of Anatomy of Domestic and Wild Animals School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Veterinary Medicine Faculty of Animal Science and Food Engineering University of S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.07.030"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2016.09.036"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-4075"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-5132"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.02.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.22456\/1679-9216.92100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(99)75474-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)70204-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77212-X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.12.020"},{"key":"e_1_2_9_12_1","first-page":"358","volume-title":"Introdu\u00e7\u00e3o \u00e0 bioqu\u00edmica cl\u00ednica veterin\u00e1ria","author":"Gonz\u00e1lez F. 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