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The transcriptomic activity of the anterior pituitary gland may be important for the control of the peri\u2010implantation period. The aim of this study was to determine the alternations in the transcriptomic profile of porcine anterior pituitary gland during the peri\u2010implantation period (days 15\u201316 of pregnancy) in comparison with established for the respective days of the oestrous cycle. Analysis using a microarray approach indicated that the 651 genes (fold\u2010change \u02c21.2;<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a0.05) were differentially expressed (DEGs) in the anterior pituitary of pigs during the peri\u2010implantation period when compared to cyclic females. Of these DEGs, 404 were upregulated and 247 downregulated. Analysis of occurred relationships among DEGs revealed that some of them are involved in steroid\u2010response and oestrogen synthesis, FSH secretion, immune response, PPAR signalling pathway and the potential for DNA methylation. In conclusion, the altered transcriptomic profile of the porcine pituitary gland in pigs during the peri\u2010implantation period indicates the role of embryos presence in the creation of transcriptomic activity of the pituitary gland in pigs.<\/jats:p>","DOI":"10.1111\/rda.13794","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T21:13:24Z","timestamp":1596489204000},"page":"1434-1445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transcriptomic analysis of the porcine anterior pituitary gland during the peri\u2010implantation period"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-130X","authenticated-orcid":false,"given":"Agata","family":"Zmijewska","sequence":"first","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-7465","authenticated-orcid":false,"given":"Wioleta","family":"Czelejewska","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa M.","family":"Waszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-2459","authenticated-orcid":false,"given":"Alina","family":"Gajewska","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Science Jablonna Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislaw","family":"Okrasa","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-8207","authenticated-orcid":false,"given":"Anita","family":"Franczak","sequence":"additional","affiliation":[{"name":"Department of Animal Anatomy and Physiology Faculty of Biology and Biotechnology University of Warmia and Mazury in Olsztyn Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"issue":"10","key":"e_1_2_9_2_1","first-page":"1953","article-title":"Gross ovarian changes during estrous cycle of swine","volume":"29","author":"Akins E. 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