{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:08:55Z","timestamp":1761664135571,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["422799\/2016\u20105"],"award-info":[{"award-number":["422799\/2016\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/16118\u20105"],"award-info":[{"award-number":["2009\/16118\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the second largest chromosome of the genome, the X chromosome is usually excluded from genome\u2010wide association studies (GWAS). Considering the presence and importance of genes on this chromosome that are involved in reproduction, the aim of this study was to evaluate the effect of its inclusion in GWAS on reproductive traits (scrotal circumference [SC], early pregnancy [P16] and age at first calving [AFC]) in a Nelore herd. Genotype data from 3,263 animals with the above\u2010mentioned phenotypes were used. The results showed an increase in the variances explained by the autosomal markers for all traits when the X chromosome was not included. For SC, there was an increase of more than 10% for the windows on chromosomes 2 and 6. For P16, the effect was increased by almost 20% for windows on chromosome 5. The same pattern was found for AFC, with an increase of more than 10% for the most important windows. The results indicate that the noninclusion of the X chromosome can overestimate the effects of autosomes on SC, P16 and AFC not only because of the additive effect of the X chromosome itself but also because of its epistatic effect on autosomal genes.<\/jats:p>","DOI":"10.1111\/rda.13810","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T14:07:07Z","timestamp":1598623627000},"page":"1650-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mapping genomic regions for reproductive traits in beef cattle: Inclusion of the X chromosome"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7285-0384","authenticated-orcid":false,"given":"Iara Del Pilar Solar","family":"Diaz","sequence":"first","affiliation":[{"name":"Escola de Medicina Veterin\u00e1ria e Zootecnia Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg\u00f3rio Miguel Ferreira","family":"de Camargo","sequence":"additional","affiliation":[{"name":"Escola de Medicina Veterin\u00e1ria e Zootecnia Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdecy Aparecida Rocha da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Escola de Medicina Veterin\u00e1ria e Zootecnia Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isis da Costa","family":"Hermisdorff","sequence":"additional","affiliation":[{"name":"Escola de Medicina Veterin\u00e1ria e Zootecnia Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Victor Damasceno","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Oeste da Bahia (UFOB)  Barra Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Galv\u00e3o","family":"de Albuquerque","sequence":"additional","affiliation":[{"name":"Departamento de Zootecnia Faculdade de Ci\u00eancias Agr\u00e1rias e Veterin\u00e1rias Universidade Estadual Paulista (Unesp)  Jaboticabal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Bermal","family":"Costa","sequence":"additional","affiliation":[{"name":"Escola de Medicina Veterin\u00e1ria e Zootecnia Universidade Federal da Bahia (UFBA)  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"issue":"152","key":"e_1_2_9_2_1","first-page":"157","article-title":"Influence of X\u2010chromosome markers on reproductive traits of beef cattle","volume":"2019","author":"Carvalho C. V. D.","year":"2019","journal-title":"Livestock Science"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.3168\/jds.2016-12490","article-title":"Bovine mammary gland X chromosome inactivation","volume":"100","author":"Couldrey C.","year":"2017","journal-title":"Journal of Dairy Science"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s12864-015-1595-0","article-title":"Non\u2010synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle","volume":"16","author":"De Camargo G. M. 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BLUPF90 \u2010 A flexible mixed model program in Fortran 90","year":"2020","author":"Misztal I.","key":"e_1_2_9_12_1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.3168\/jds.2019-17767","article-title":"Gene mapping and genomic prediction of bull fertility using sex chromosome markers","volume":"103","author":"Pacheco A. H.","year":"2019","journal-title":"Journal of Dairy Science"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1038\/s41467-019-10598-y","article-title":"The effect of X\u2010linked dosage compensation on complex trait variation","volume":"10","author":"Sidorenko J.","year":"2019","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_9_15_1","first-page":"s172","article-title":"Review: Genomics of bull fertility","volume":"12","author":"Taylor J. 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