{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:49:37Z","timestamp":1792000177954,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aims of the present study were to determine uterine, vaginal and placental blood flows by Doppler ultrasound cross\u2010buffalo gestation and to evaluate the relationships among reproductive Doppler parameters and serum metabolic parameters as well as oxidative stress. Uterine (UA) and vaginal (VA) arteries were scanned every month, and placentome was scanned from month 4 till 8 in gestation. Time\u2010averaged maximum velocity (TAMV), pulsatility index (PI), resistance index (RI), systolic\/diastolic ratio (<jats:italic>SD<\/jats:italic>) and arterial diameter (AD) were used for accessing UA and VA hemodynamics. Time\u2010averaged maximum velocity positively correlated with and AD, and both negatively correlated with their PI, RI and <jats:italic>SD<\/jats:italic> in UA and VA. TAMV and AD increased constantly in pregnancy, with maximum increase in months 4 and 9. Pulsatility index, RI and AD of UA decreased between months 4 and 9, while PI, RI and AD of VA decreased between months 5 and 9 and then increased in month 10 in pregnancy. Time\u2010averaged maximum velocity of placentome blood flow increased exponentially from months 4 to 8, but decreased at the last two months in pregnancy. Serum lipids were significantly higher in the first month compared to all other months, while glucose was significantly lower in months 9 and 10. Malondialdehyde increased from month 3 till term, but peaked in month 5 and 10. Glutathione and catalase were highest in the first month and remained after. Time\u2010averaged maximum velocity and AD for both UA and VA negatively correlated with serum lipids, glucose, catalase and glutathione, while positively correlated with malondialdehyde and total protein. Thus, increases in uterine blood flow (UtBF), vaginal blood flow (VaBF) and placental blood flow (PaBF) are associated with increased metabolism and oxidative stress in buffalo pregnancy.<\/jats:p>","DOI":"10.1111\/rda.13858","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T05:38:42Z","timestamp":1605073122000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Uterine, vaginal and placental blood flows increase with dynamic changes in serum metabolic parameters and oxidative stress across gestation in buffaloes"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-7756","authenticated-orcid":false,"given":"Mohammed A.","family":"Elmetwally","sequence":"first","affiliation":[{"name":"Department of Theriogenology, Veterinary Medicine Faculty Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehad E.","family":"Elshopakey","sequence":"additional","affiliation":[{"name":"Clinical Pathology, Veterinary Medicine Faculty Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Eldomany","sequence":"additional","affiliation":[{"name":"Department of Theriogenology, Veterinary Medicine Faculty Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Eldesouky","sequence":"additional","affiliation":[{"name":"Department of Theriogenology, Veterinary Medicine Faculty Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Samy","sequence":"additional","affiliation":[{"name":"Surgery, Anesthesiology and Radiology Veterinary Medicine Faculty Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Y.","family":"Lenis","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Animal Facultad de Ciencias Agrarias Universidad Nacional de Colombia Palmira Colombia"},{"name":"OHVRI\u2010Group (One Health and Veterinary Innovative Research and Development School of Veterinary Medicine Faculty of Agrarian Science Antioquia University Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010bao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of California Irvine Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019-17068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8010020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2019.06.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5194\/aab-59-429-2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.400"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-74087-4_2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(02)00706-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818806453"},{"issue":"3","key":"e_1_2_8_10_1","first-page":"171","article-title":"Study on serum glucose, insulin, NEFA, BHBA and lipid profile in different productive status of high producing Holstein dairy cows","volume":"9","author":"Chalmeh A.","year":"2015","journal-title":"Iranian Journal of Veterinary Medicine"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.05.016"},{"key":"e_1_2_8_12_1","unstructured":"Craig M. 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