{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:17:56Z","timestamp":1775953076197,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["210.503\/2019"],"award-info":[{"award-number":["210.503\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate the effects of zearalenone (ZEA) on the reproductive system morphometry, oestrogen (E2) levels and oocyte quality of beef heifers. Twenty non\u2010pregnant purebred Nellore (<jats:italic>Bos indicus<\/jats:italic>) heifers [age, \u226518\u00a0months; initial body weight, 348\u00a0\u00b1\u00a030\u00a0kg (mean\u00a0\u00b1\u00a0standard deviation)] were used. The animals were randomly divided into experimental group and a control group of 10 animals each. Group experimental was administered 300\u00a0ppb ZEA <jats:italic>per os<\/jats:italic> for 98\u00a0days, and the control group was administered placebo <jats:italic>per os<\/jats:italic> for 98\u00a0days. The administration of ZEA was carried out daily by adding mycotoxin to the diet. All heifers were evaluated weekly via rectal ultrasound examinations (12\u00a0weeks). Diameters of the right and left uterine horns, right and left ovaries, largest antral follicle and corpus luteum were measured. Vulva size was also measured. Blood samples were collected to estimate E2 levels. At the end of 12\u00a0weeks, the heifers were slaughtered, and the ovaries were sent to the laboratory for in vitro embryo production. A completely randomized design was adopted, and repeated measures analysis of variance (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) was performed (except for oocyte quality). Vulva size (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0985); diameters of uterine horns (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0522), ovaries (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.6955), antral follicles (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.6355) and corpus luteum (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.3808); and E2 levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.3379) were not affected by the treatments. ZEA\u2010contaminated diet significantly reduced (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.05) the proportion of viable oocytes (49.4%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0207) compared with the control diet (59.9%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0222); however, the blastocyst rate did not differ between the groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.9418). The results indicate that contamination of beef heifer's diet with 300\u00a0ppb ZEA affected neither morphometric parameters nor plasma oestrogen levels; however, ZEA contamination was detrimental to oocyte quality.<\/jats:p>","DOI":"10.1111\/rda.13917","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T14:45:10Z","timestamp":1613745910000},"page":"775-782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<b>Effects of experimental exposure to zearalenone on reproductive system morphometry<\/b>, <b>plasma oestrogen levels, and oocyte quality of beef heifer<\/b>"],"prefix":"10.1111","volume":"56","author":[{"given":"Lucas de Almeida","family":"Silva","sequence":"first","affiliation":[{"name":"Animal Science Graduate Program Universidade Federal Rural do Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-4764","authenticated-orcid":false,"given":"Marco Roberto Bourg","family":"de Mello","sequence":"additional","affiliation":[{"name":"Institute of Animal Science Universidade Federal Rural do Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle de","family":"Oliveira Pi\u00e3o","sequence":"additional","affiliation":[{"name":"Animal Science Graduate Program Universidade Federal Rural do Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara Nogueira","family":"Silenciato","sequence":"additional","affiliation":[{"name":"Animal Science Graduate Program Universidade Federal Rural do Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thays Cristina Oliveira","family":"de Quadros","sequence":"additional","affiliation":[{"name":"Cargill Animal Nutrition Incorporation Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Henryli","family":"de Souza","sequence":"additional","affiliation":[{"name":"Cargill Animal Nutrition Incorporation Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rondineli Pavezzi","family":"Barbero","sequence":"additional","affiliation":[{"name":"Institute of Animal Science Universidade Federal Rural do Rio de Janeiro Serop\u00e9dica Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"ABIEC. (2019).Beef Report. Brazilian Livestock Profile. S\u00e3o Paulo \u2010 SP: ABIEC \u2010 Associa\u00e7\u00e3o Brasileira das Ind\u00fastrias Exportadoras de Carne. (Accessed 07 November 2020).http:\/\/ABIEC.com.br\/publicacoes\/beef\u2010report\u20102019\/"},{"key":"e_1_2_10_3_1","first-page":"159","article-title":"Mycotoxins in Foods and Feeds 3\u2010Zearalenone","volume":"7","author":"Agag B. 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