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We compared the cord serum metabolic profiles and biochemical indexes of SCNT\u2010derived piglets that died within 4\u00a0days (SCNT\u2010DW4), SCNT\u2010derived piglets that survived over 4\u00a0days (SCNT\u2010SO4) and artificial insemination (AI)\u2010generated piglets that survived over 4\u00a0days (AI\u2010SO4) to investigate the associations of serum metabolomics and biochemical indexes in umbilical cord (UC) sera at delivery with the neonatal loss of cloned pigs. Results showed that compared with SCNT\u2010SO4 and AI\u2010SO4 piglets, SCNT\u2010DW4 piglets had lower birth weight, placental indexes, placental vascularization scores, UC scores, vitality scores, serum glucose and levels but higher creatinine, urea nitrogen and uric acid levels in cord sera. Metabolomics analysis revealed alterations in lipid, glucose and purine metabolism in the cord sera of SCNT\u2010DW4 piglets. These results indicated that the disturbance of the cord serum metabolome might be associated with the low birth weight and malformations of cloned neonates. These effects were likely the consequences of the impaired placental morphology and function of SCNT\u2010derived piglets. This study provides helpful information regarding the potential mechanisms responsible for the neonatal death of cloned pigs and also offers an important basis for the design of effective strategies to improve the survival rate of these animals.<\/jats:p>","DOI":"10.1111\/rda.14014","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T18:45:11Z","timestamp":1630953911000},"page":"1519-1528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of cord metabolome and biochemical parameters with the neonatal deaths of cloned pigs"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-8752","authenticated-orcid":false,"given":"Zheng","family":"Ao","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region Ministry of Education College of Animal Science Guizhou 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