{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:51:14Z","timestamp":1783648274306,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to identify the impact of <jats:italic>Trueperella pyogenes<\/jats:italic> in cows with clinical endometritis (CE) on reproductive performance and milk production in affected cows. In total, 230 lactating Holstein dairy cows from six commercial dairy herds were sampled once between 28 and 33\u00a0days post\u2010partum. Cows included in the present study did not receive antibiotic or anti\u2010inflammatory treatments prior to the experimental period. Clinical endometritis (CE) was characterized as cow with vaginal mucus score\u00a0=\u00a03 (&gt;50% of purulent vaginal discharge) and &gt;18% polymorphonuclear neutrophilic leukocyte (PMNL). The body condition scores (BCS) and milk production were evaluated at the time of enrolment. The identification of isolated bacteria was carried out through the analysis of MALDI\u2010TOF MS (matrix\u2010assisted laser desorption ionization time\u2010of\u2010flight mass spectrometry). According to uterine health, three groups of dairy cows were formed: healthy control cows without <jats:italic>T.\u00a0pyogenes<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0147), CE cows with <jats:italic>T.\u00a0pyogenes<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) and CE cows without <jats:italic>T.\u00a0pyogenes<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a061). CE cows with <jats:italic>T.\u00a0pyogenes<\/jats:italic> had lower BCS, milk production and conception at first AI (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) than CE cows without <jats:italic>T.\u00a0pyogenes<\/jats:italic> and control cows. Furthermore, CE cows with <jats:italic>T.\u00a0pyogenes<\/jats:italic> had higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) service per pregnancy and had greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) days to get pregnant than CE cows without <jats:italic>T.\u00a0pyogenes<\/jats:italic> and control cows. This study demonstrates that CE cows with <jats:italic>T.\u00a0pyogenes<\/jats:italic> had impaired reproductive performance and milk production when compared to cows without CE and CE cows without <jats:italic>T.\u00a0pyogenes<\/jats:italic>. This information can contribute to a strategic treatment in cows affected by clinical endometritis, favouring the rational use of antibiotics on dairy farms.<\/jats:p>","DOI":"10.1111\/rda.14017","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T16:57:02Z","timestamp":1631465822000},"page":"1536-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical endometritis with <i>Trueperella pyogenes<\/i> reduces reproductive performance and milk production in dairy cows"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1039-371X","authenticated-orcid":false,"given":"Renan B.","family":"Paiano","sequence":"first","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o Animal Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-0096","authenticated-orcid":false,"given":"Jeannine","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia de Alimentos Faculdade de Zootecnia e Engenharia de Alimentos Universidade de S\u00e3o Paulo Pirassununga Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3290-566X","authenticated-orcid":false,"given":"Andrea M.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva e Sa\u00fade Animal Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-4450","authenticated-orcid":false,"given":"Pietro S.","family":"Baruselli","sequence":"additional","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o Animal Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.07.030"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2015.09.043"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2015-10401"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2020.06.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-3356"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250-014-0661-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2019.07.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77212-X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019-17106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2009-2551"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.04.022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(97)76275-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.035774-0"},{"key":"e_1_2_10_15_1","first-page":"S15","article-title":"Factors contributing to immunosuppression in the dairy cow during the periparturient period","volume":"63","author":"Ingvartsen K. 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