{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:45:35Z","timestamp":1771328735989,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to ascertain whether premature luteolysis can be alleviated by substituting the ovulation inducing agent hCG for GnRH. Seventy\u2010two hours after the end of artificial insemination (AI), pluriparous Awassi ewes were randomly assigned to one of three treatment groups of 13 ewes each. First group received 37.5\u00a0\u00b5g of the GnRH analog Lecirelin, the second 1000\u00a0I.U hCG and the third group served as a control (received 1\u00a0ml of physiological saline solution). Blood samples were collected at daily intervals after GnRH treatment and analysed for plasma oestradiol and progesterone concentrations. Ovarian follicles were monitored ultrasonically at the time of GnRH administration, 60\u00a0hr and 84\u00a0hr later. Pregnancy was diagnosed ultrasonically at Day 35 after AI. Number and size of ovarian follicles did not differ (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05) among treatment groups. Onset and duration of oestrus were not affected by treatment (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). No significant differences (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05) were recorded in oestradiol and progesterone concentrations between the treatment groups during the inspection period. Premature luteolysis became evident in ewes with longer oestrous durations by Day 6.25 after AI and amounted to 7.69%, 18.18% and 23.07% in GnRH, hCG and Control groups respectively. Pregnancy rates increased to 92.31% and 81.82% in GnRH and hCG groups, compared to 76.92% in the Control group. The results indicate that GnRH was more effective in reducing premature luteolysis than hCG. Substituting hCG for GnRH as an ovulation inducing agent was of no avail.<\/jats:p>","DOI":"10.1111\/rda.14094","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T03:14:21Z","timestamp":1644376461000},"page":"550-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of GnRH and hCG effects on oestradiol, progesterone and premature luteolysis in Ovsynch\u2010synchronized ewes"],"prefix":"10.1111","volume":"57","author":[{"given":"Abir","family":"Salloum","sequence":"first","affiliation":[{"name":"Department of Animal Production University of Damascus  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-2897","authenticated-orcid":false,"given":"Mohammed","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Animal Production University of Damascus  Damascus Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2012.01.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2007.12.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2006.01.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs2008.9.1.95"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093\u2010691X(83)90070\u20105"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301\u20106226(95)00023\u2010E"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2527\/2001.7971675x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093\u2010691X(98)00068\u20105"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:19850101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2004.01.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008088783-8.00033-4"},{"issue":"1","key":"e_1_2_8_13_1","first-page":"33","article-title":"Drugs which inhibit prostaglandin biosynthesis","volume":"26","author":"Flower R. 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