{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:47:29Z","timestamp":1772257649774,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometritis is an important issue decreasing mares' fertility. In the case of endometritis, both inflammatory cells infiltration and proinflammatory molecules production are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor\u2010\u03baB (NF\u2010\u03baB)\u2010dependent pathway. NF\u2010\u03baB\u2010signalling pathway has been recently studied in the equine endometrium in the context of endometrosis. Thus, this study aimed to determine gene transcription of NF\u2010\u03baB subunits (<jats:italic>RelA; NF\u2010\u03baB1; NF\u2010\u03baB2<\/jats:italic>), proinflammatory molecules (<jats:italic>MCP\u20101; IL\u20106<\/jats:italic>) and hyaluronan synthases (<jats:italic>HAS 1; HAS 2; HAS 3<\/jats:italic>) in endometritis and compare them with the intensity and type of inflammatory cell infiltration. Endometrial samples, collected post\u2010mortem from cyclic mares in oestrus or dioestrus, were classified histologically and examined using quantitative PCR. Transcription NF\u2010\u03baB subunits genes did not differ with either inflammatory intensity or type of inflammatory cell infiltration. Transcription of <jats:italic>MCP\u20101<\/jats:italic> and <jats:italic>IL\u20106<\/jats:italic> genes increased with the severity of inflammation, with the involvement of <jats:italic>HAS 3<\/jats:italic> and <jats:italic>HAS 2<\/jats:italic> genes, as opposed to <jats:italic>HAS 1<\/jats:italic> genes. These proinflammatory molecules and hyaluronan synthases in the equine inflamed endometrium do not seem to be regulated by the NF\u2010\u03baB pathway. Hence, separate signalling pathways for the development and progression of equine endometritis and endometrosis may be suggested.<\/jats:p>","DOI":"10.1111\/rda.14099","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T10:23:07Z","timestamp":1645266187000},"page":"598-610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The NF\u2010\u03baB\u2010signalling pathway in mare's endometrium infiltrated with the inflammatory cells"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-9944","authenticated-orcid":false,"given":"Tomasz","family":"Jasi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Large Animal Diseases and Clinic Institute of Veterinary Medicine Warsaw University of Life Sciences (WULS \u2013 SGGW)  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4401-9016","authenticated-orcid":false,"given":"\u0141ukasz","family":"Zdrojkowski","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases and Clinic Institute of Veterinary Medicine Warsaw University of Life Sciences (WULS \u2013 SGGW)  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8240-1224","authenticated-orcid":false,"given":"Ewa","family":"Kautz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences  Jastrz\u0119biec Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-5320","authenticated-orcid":false,"given":"Edyta","family":"Juszczuk\u2010Kubiak","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Molecular Engineering Department of Microbiology Prof. Wac\u0142aw D\u0105browski Institute of Agricultural and Food Biotechnology\u2014State Research Institute  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-6513","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Ferreira\u2010Dias","sequence":"additional","affiliation":[{"name":"Departmento de Morfologia e Fun\u00e7\u00e3o CIISA \u2010 Centro de Investiga\u00e7\u00e3o Interdisciplinar em Sanidade Animal Faculdade de Medicina Veterin\u00e1ria Universidade de Lisboa  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9436-1074","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Domino","sequence":"additional","affiliation":[{"name":"Department of Large Animal Diseases and Clinic Institute of Veterinary Medicine Warsaw University of Life Sciences (WULS \u2013 SGGW)  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4142\/jvs.2012.13.2.171"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod61.1.85"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-8-41"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0936-6768.2003.00464.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2006.03.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2020.01.055"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(03)00137-5"},{"key":"e_1_2_11_10_1","volume-title":"Morphometric determination of endometrial leukocyte migration during different stages of the equine oestrous cycle","author":"Gerber D.","year":"2006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2021.05.011"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11113151"},{"key":"e_1_2_11_13_1","first-page":"723","volume-title":"Current therapy in theriogenology","author":"Kenney R. 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