{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:56:02Z","timestamp":1790672162226,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The work was aimed to research into the vital signs, haematological and biochemical parameters, acute\u2010phase protein concentrations (CRP, albumin), progesterone (PG) and anti\u2010M\u00fcllerian hormone (AMH) concentrations in bitches with pyometra and their comparison with those in healthy bitches. In addition, the goal of this work was to assess if some of the tested parameters may be used as a biomarker in the diagnostics of pyometra and the monitoring of the postoperative recovery. Forty 3\u20106\u2010year\u2010old bitches of various breeds were included in the research and allotted to two groups: the control (C, <jats:italic>n<\/jats:italic>\u00a0=\u00a020) and the diseased \u2013 bitches diagnosed with pyometra (P, <jats:italic>n<\/jats:italic>\u00a0=\u00a020). Blood samples for the analyses were taken immediately before surgery (0\u00a0h), and 12\u2009h, 24\u2009h, 48\u2009h and 72\u2009h after, excepting for AMH and PG concentrations, which were determined only at 0\u00a0h. Clinical examination detected significantly higher respiration rates in bitches with pyometra in comparison to healthy ones at all time points, higher heart rates before and 12\u2009h after surgery, and higher body temperature before and 12\u2009h, 48\u2009h and 72\u2009h post operation (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><jats:p>Significantly higher concentrations of CRP (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01) and lower concentrations of albumin were detected in bitches with pyometra in comparison to their healthy counterparts at all time points. Progesterone and AMH concentration analysis immediately before surgery detected significantly higher levels of the hormone in bitches with pyometra than in the control (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The inflammatory reaction of the endometrium resulted in a significant AMH concentration increase, whilst increased CRP concentrations and lower albumin concentrations throughout the research may be used as biomarkers of proinflammatory activities, that is of the acute\u2010phase response.<\/jats:p>","DOI":"10.1111\/rda.14186","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T07:31:44Z","timestamp":1655278304000},"page":"1156-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of the concentrations of some haematological parameters, C\u2010reactive protein and <scp>anti\u2010M\u00fcllerian<\/scp> hormone in bitches affected by pyometra"],"prefix":"10.1111","volume":"57","author":[{"given":"Du\u0161an","family":"Jankovi\u0107","sequence":"first","affiliation":[{"name":"Evidensia Djursjukhuset Malm\u00f6  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Norrman","sequence":"additional","affiliation":[{"name":"Evidensia Djursjukhuset Malm\u00f6  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Aronsson","sequence":"additional","affiliation":[{"name":"Evidensia Djursjukhuset Malm\u00f6  Malmo Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Vojvodi\u0107","sequence":"additional","affiliation":[{"name":"Military Medical Academy  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milorad","family":"Mirilovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Statistics and Economics University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branislav","family":"Vejnovi\u0107","sequence":"additional","affiliation":[{"name":"Department for Statistics and Economics University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljubodrag","family":"Stani\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8584-3653","authenticated-orcid":false,"given":"Svetlana","family":"Nedi\u0107","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Maleti\u0107","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miloje","family":"\u0110uri\u0107","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Maga\u0161","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-7559","authenticated-orcid":false,"given":"Slobodanka","family":"Vakanjac","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Fertility and Artificial Insemination University of Belgrade Faculty of Veterinary Medicine  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.03.035"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2014.11.016"},{"issue":"9","key":"e_1_2_10_4_1","first-page":"378","article-title":"Pyometra in the dog. 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