{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:56:25Z","timestamp":1788432985010,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Camelids have many unique reproductive features that considerably differ from those of other domestic species. Females are induced ovulators with subsequent development of a corpus luteum (CL) with a short lifespan. Plasma progesterone concentration starts to increase on day 4, peaks on day 8\u20139 and, in non\u2010pregnant animals, basal concentration is reached around day 10\u201311 post\u2010induction of ovulation. Luteolytic pulses of prostaglandin F<jats:sub>2\u03b1<\/jats:sub> (PGF<jats:sub>2\u03b1<\/jats:sub>) are firstly detected on day 7 or 8 (approximately on day 5\u20136 after ovulation), with maximal luteolytic peaks observed between days 9 and 11 post\u2010mating, in coincidence with a high endometrial expression of cyclooxygenase 2, a limiting enzyme in prostaglandins synthesis. Unlike other species, oxytocin seems not to be involved in the luteolytic process in these species. The CL is the main source of progesterone secretion, and its function is required to support pregnancy. Despite constant research efforts, aspects of reproduction and maternal recognition of pregnancy in camelids remain not fully understood. A transient decrease and subsequent recovery in plasma progesterone concentration are observed after day 9 post\u2010mating in pregnant animals in association with a pulsatile release of PGF<jats:sub>2\u03b1<\/jats:sub> and a transitory decrease in CL vascularization. Thus, embryo recognition should occur between days 8 and 12 post\u2010mating. In camels, conceptus tissues exhibit aromatizing activity with the capacity to synthesize large amounts of oestradiol. Similarly, llama blastocysts secrete oestradiol\u201017\u03b2 during the preimplantation stage, with a higher production during the elongation period. An increase in the endometrial expression of oestrogen receptor \u03b1 is also observed on day 12 post\u2010mating. All these evidences suggest that oestrogen could be the signal released by the embryo at the time of its recognition in camelids. Besides, nearly 98% of pregnancies are carried out in the left horn. A decrease in the endometrial expression of mucin 1 and 16 genes has been reported, suggesting that these changes are crucial for successful embryo implantation; however, no differences have been observed between horns. Thus, maternal recognition of pregnancy in camelids is a particularly complex process that must occur in a concise time to allow the rescue of the CL and embryo survival.<\/jats:p>","DOI":"10.1111\/rda.14269","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T13:54:28Z","timestamp":1663941268000},"page":"3-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Current knowledge about the processes of luteolysis and maternal recognition of pregnancy in camelids"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-8356","authenticated-orcid":false,"given":"Carolina Paula","family":"Bianchi","sequence":"first","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda, Facultad de Ciencias Veterinarias Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"},{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN) CONICET \u2013 CICPBA \u2013 Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"},{"name":"CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-6052","authenticated-orcid":false,"given":"Maria F.","family":"Gallelli","sequence":"additional","affiliation":[{"name":"CONICET  Buenos Aires Argentina"},{"name":"C\u00e1tedra de Teriogenolog\u00eda, Facultad de Ciencias Veterinarias Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Facultad de Ciencias Veterinarias, Instituto de Investigaci\u00f3n y Tecnolog\u00eda en Reproducci\u00f3n Animal (INITRA) Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-6243","authenticated-orcid":false,"given":"Juan Manuel","family":"Herrera","sequence":"additional","affiliation":[{"name":"Laboratorio de Histolog\u00eda y Embriolog\u00eda, Facultad de Ciencias Veterinarias Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-9600","authenticated-orcid":false,"given":"Micaela A.","family":"Benavente","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda, Facultad de Ciencias Veterinarias Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"},{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN) CONICET \u2013 CICPBA \u2013 Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"},{"name":"CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0120-0015","authenticated-orcid":false,"given":"Liliana","family":"Rossetto","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Reproducci\u00f3n Animal, Facultad de Ciencias Veterinarias Universidad Nacional de La Pampa  General Pico Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-275X","authenticated-orcid":false,"given":"Marcelo Alfredo","family":"Aba","sequence":"additional","affiliation":[{"name":"Laboratorio de Endocrinolog\u00eda, Facultad de Ciencias Veterinarias Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"},{"name":"Centro de Investigaci\u00f3n Veterinaria de Tandil (CIVETAN) CONICET \u2013 CICPBA \u2013 Universidad Nacional del Centro de la Provincia de Buenos Aires  Tandil Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Aba M.A.&Bianchi C.P.(2014).La exposici\u00f3n continua a concentraciones elevadas de oxitocina no logra inhibir el proceso de lute\u00f3lisis en llamas. 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