{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:37:04Z","timestamp":1783489024006,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to determine the impact of different strategies for increasing the level of serum progesterone (P4) on luteal morphology and function in bovine females. The effects of increasing P4 on pregnancy rate and gestational loss (GL) in Nelore cows subjected to timed artificial insemination (TAI) were also evaluated. A total of 939 cows were divided into three groups: P4LA (<jats:italic>n<\/jats:italic>\u00a0=\u00a0305), 150\u2009mg of long\u2010acting injectable P4 7\u2009days after TAI; GnRH (<jats:italic>n<\/jats:italic>\u00a0=\u00a0306), 10\u00a0\u03bcg of buserelin acetate 7\u2009days after TAI; and control (<jats:italic>n<\/jats:italic>\u00a0=\u00a0328), no hormone treatment after TAI. Doppler ultrasound assessments and P4 measurements were performed on days 7 and 16 after TAI. The pregnancy rate and GL as a function of treatment were compared using the SAS GLIMMIX procedure. Corpus luteum (CL) vascular perfusion, volume, and plasma P4 concentration were analysed using the SAS PROC MIXED procedure. No significant difference was found among the treatments in terms of volume, number of pixels, and CL intensity or in the serum P4 concentration at 7\u2009days after ovulation. The CL blood flow at 16\u2009days after ovulation was lower in the P4LA and GnRH groups than that in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Serum concentrations of P4 at 16\u2009days after ovulation were higher in the P4LA and GnRH groups than those in the control group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). A difference in the pregnancy rate (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003) and a trend in GL (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.07) as a function of treatment were found. Overall, long\u2010acting injectable P4 supplementation on day 7 after TAI or GnRH administration affected CL vascularization and increased the serum concentrations of P4 16\u2009days after ovulation, promoting better pregnancy rates than the control.<\/jats:p>","DOI":"10.1111\/rda.14288","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T10:59:51Z","timestamp":1667991591000},"page":"314-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of increased serum progesterone on luteal morphology and function, pregnancy, and gestational loss in Nelore cows"],"prefix":"10.1111","volume":"58","author":[{"given":"Samuel R. B.","family":"Couto","sequence":"first","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o e Avalia\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri B.","family":"Guerson","sequence":"additional","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o e Avalia\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M. P. M.","family":"Caparelli","sequence":"additional","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o e Avalia\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-3710","authenticated-orcid":false,"given":"Jo\u00e3o Paulo N.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio C. F.","family":"Jacob","sequence":"additional","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o e Avalia\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-395X","authenticated-orcid":false,"given":"Rondineli P.","family":"Barbero","sequence":"additional","affiliation":[{"name":"Departamento de Produ\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-4764","authenticated-orcid":false,"given":"Marco R. B.","family":"Mello","sequence":"additional","affiliation":[{"name":"Departamento de Reprodu\u00e7\u00e3o e Avalia\u00e7\u00e3o Animal Universidade Federal Rural do Rio de Janeiro  Serop\u00e9dica Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2004.04.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.33899\/ijvs.2019.153842"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2004.05.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2019.02.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2009.04.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2008.12.014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2019\u201016439"},{"key":"e_1_2_10_9_1","first-page":"121","article-title":"Programa\u00e7\u00e3o da receptividade uterina e fertilidade em vacas de corte","volume":"41","author":"Binelli M.","year":"2017","journal-title":"Revista Brasileira de Reprodu\u00e7\u00e3o Animal"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2018.10.032"},{"key":"e_1_2_10_11_1","first-page":"583","volume-title":"The Vertebrate Ovary. 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