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Oestrus was synchronized in 774 adult Kazak ewes using an intravaginal sponge impregnated with flurogestone acetate. The sponge was left in the vagina for 12\u2009days followed with an injection of 330\u2009IU of eCG at sponge removal. Each ewe was inseminated twice at 48\u2009h and 60\u2009h after sponge removal. The treatment group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0387) was intramuscularly injected at the first insemination with a dose of 25\u2009\u03bcg GnRH and the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0387) with saline solution. The results showed that GnRH administration significantly decreased the fertility rate. In addition, significant differences were observed between the two groups in terms of the twin birth rate, the abortion rate and the litter size. In conclusion, GnRH administration at insemination was not recommended in Kazak ewes undergoing the fixed time artificial insemination during the breeding season. The breed may be a critical determinant of the potential for the exploitation of GnRH application in sheep breeding programmes.<\/jats:p>","DOI":"10.1111\/rda.14306","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T06:58:26Z","timestamp":1671433106000},"page":"465-469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of exogenous <scp>GnRH<\/scp> administration on lambing performance of oestrus\u2010synchronized Kazak ewes during the breeding season"],"prefix":"10.1111","volume":"58","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Hebei Technology Innovation Center of Cattle and Sheep Embryo Hebei Agricultural University  Baoding Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Institute of 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