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A total of 66 ewes were randomly assigned into four groups: CIDR (<jats:italic>n<\/jats:italic>\u2009=\u200916): exposed to intravaginal CIDR for 12\u2009days, and three experimental groups, i.e., T<jats:sub>100<\/jats:sub> (<jats:italic>n<\/jats:italic>\u2009=\u200916)<jats:sub>,<\/jats:sub> T<jats:sub>150<\/jats:sub> (<jats:italic>n<\/jats:italic>\u2009=\u200917) and T<jats:sub>200<\/jats:sub> (<jats:italic>n<\/jats:italic>\u2009=\u200917), receiving a single intramuscular injection of 100, 150 and 200\u2009mg slow\u2010release progesterone, respectively. Blood sampling was performed on all ewes at five different times, and the ELISA method measured progesterone levels. No significant differences were observed in progesterone levels among the groups in each sampling time. More than 90% of ewes in the CIDR, T<jats:sub>100<\/jats:sub> and T<jats:sub>150<\/jats:sub> groups and all those in T<jats:sub>200<\/jats:sub> showed estrus behaviour, and the rate was not significantly different between groups. The difference in the mean interval from progesterone treatment to estrus was also insignificant. The parturition rate declined by increasing the dose of injected progesterone; although it was similar in CIDR and T<jats:sub>100<\/jats:sub> groups, it decreased significantly in T<jats:sub>150<\/jats:sub> and T<jats:sub>200<\/jats:sub>. Since our injectable progesterone formulation was successful in the induction and synchronization of estrus in ewes out of the breeding season, it can be applied as an alternative to the conventional progesterone containing intravaginal devices.<\/jats:p>","DOI":"10.1111\/rda.14370","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T09:15:39Z","timestamp":1683018939000},"page":"935-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development and evaluation of an injectable slow\u2010release progesterone formulation for estrus synchronization in ewes out of the breeding season"],"prefix":"10.1111","volume":"58","author":[{"given":"Mohsen","family":"Vafaei\u00a0Salarpoor","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3221-9635","authenticated-orcid":false,"given":"Ali","family":"Kadivar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Shahrekord University  Shahrekord Iran"},{"name":"Research Institute of Animal Embryo Technology Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najmeh","family":"Davoodian","sequence":"additional","affiliation":[{"name":"Research Institute of Animal Embryo Technology Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Khosravian","sequence":"additional","affiliation":[{"name":"Institute of Basic Health Sciences, Medicinal Plants Research Center Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-1722","authenticated-orcid":false,"given":"Naser","family":"Shams\u00a0Esfandabadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Shahrekord University  Shahrekord Iran"},{"name":"Research Institute of Animal Embryo Technology Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdonnaser","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Faculty of Veterinary Medicine Shahrekord University  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Mehrban","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture Shahrekord University  Shahrekord Iran"},{"name":"Animal Science Research Institute of Iran, Agriculture Research, Education, and Extension Organization (AREEO)  Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.18805\/ijar.B\u2010646"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2011.02.024"},{"key":"e_1_2_10_4_1","first-page":"335","article-title":"Control of antral follicle development and selection in sheep and cattle","volume":"49","author":"Campbell B. 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