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In particular, chronic stress can disrupt the delicate balance of the hormonal system that regulates reproductive function, leading to a variety of reproductive disorders and fertility issues. Beside the action of the hypothalamic\u2010pituitary\u2010adrenal (HPA) system and the sympatho\u2010adrenomedullary system (SAM), other subsequent mechanisms have been incriminated. Thus, stress has also been associated with increased prolactin level, resulting in an inhibition of the hypothalamo\u2010pituitary\u2010gonadal (HPG) system leading to several reproductive disorders. Thyroid function is inhibited during chronic stress, and therefore considered an important regulator of reproductive function. Thus, and in particular by interfering with the HPA system, stress\u2010induced immune dysregulation can have adverse effects on reproduction. In addition, oxidative stress and inflammation have been proposed as potential mechanisms by which chronic stress affects reproductive function. This is caused by an increase in reactive oxygen species (ROS) production that has a harmful effect on cells. Furthermore, inflammation can lead to tissue damage and scarring, which can affect fertility. The present review completes the complex mechanism linking stress and reproduction through the current knowledge in various animal species in a comparative point of view.<\/jats:p>","DOI":"10.1111\/rda.14445","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T11:01:28Z","timestamp":1695121288000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pathogenesis of the crosstalk between reproductive function and stress in animals \u2013 part 2: Prolactin, thyroid, inflammation and oxidative stress"],"prefix":"10.1111","volume":"58","author":[{"given":"Laetitia","family":"Jaillardon","sequence":"first","affiliation":[{"name":"Oniris, LabOniris, Nantes Atlantic National College of Veterinary Medicine Food Sciences and Engineering  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9962-5582","authenticated-orcid":false,"given":"Marianne","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Management and Modelling Department of Animal and Veterinary Sciences Faculty of Technical Sciences Aarhus University  Tjele Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001224\u20109"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10081203"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13003"},{"key":"e_1_2_10_5_1","unstructured":"Busch M. 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