{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T02:19:34Z","timestamp":1778552374930,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008708","name":"Australian Wool Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the sheep breeding season, ovulatory follicles vary widely in age at pessary removal impacting both the timing of oestrus and pregnancy rates following artificial insemination (AI). Ovulatory follicles that emerge between days 7 to 9 of the pessary period are associated with higher fertility whilst those that emerge earlier or later are associated with lower fertility. In this study, two strategies to improve the success of AI by controlling the development of the ovulatory follicle were examined. In the first, ewes were treated with PGF2\u03b1 at either \u221212 and\/or +6\u2009days (experiment 1) or \u221227\u2009days (experiment 2) relative to pessary insertion to control the time of emergence of the ovulatory follicle. In the second, ewes were treated with eCG (400\u2009IU per ewe) at either 0\u2009h, \u22126\u2009h or \u221212\u2009h relative to pessary removal (experiment 3) to improve the development of young ovulatory follicles. PGF2\u03b1 administered on day \u221227 increased the percentage of pregnant ewes by 17.8% and the number of foetuses per 100 ewes inseminated by 33.9%. PGF2\u03b1 treatment at other times had either no effect or reduced fertility. During the breeding season, treatment with eCG at \u221212\u2009h improved the synchrony of oestrus, reduced the size of the ovulatory follicle but did not improve pregnancy rate compared with other treatments. Treatment had no effect during the non\u2010breeding season, supporting earlier findings that the quality of young ovulatory follicles differs during the year. In conclusion, PGF2\u03b1 treatment 27\u2009days before pessary insertion provides a new and cheap strategy to improve the success of fixed\u2010time AI programs.<\/jats:p>","DOI":"10.1111\/rda.14450","type":"journal-article","created":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:57:50Z","timestamp":1691888270000},"page":"1359-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Strategies to improve the success of fixed\u2010time artificial insemination in the ewe"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-8275","authenticated-orcid":false,"given":"Alice C.","family":"Weaver","sequence":"first","affiliation":[{"name":"Turretfield Research Centre South Australian Research and Development Institute  Rosedale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre South Australian Research and Development Institute  Rosedale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyce M.","family":"Swinbourne","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre South Australian Research and Development Institute  Rosedale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-7730","authenticated-orcid":false,"given":"David O.","family":"Kleemann","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre South Australian Research and Development Institute  Rosedale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon K.","family":"Walker","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre South Australian Research and Development Institute  Rosedale South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093\u2010691X(85)90054\u20108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smallrumres.2006.07.017"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2527\/1999.7782219x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0093\u2010691x(02)01038\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0550015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0021859600040909"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0021859600060184"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0340357"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2015.11.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0093\u2010691x(91)90148\u20107"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0093\u2010691x(01)00619\u20107"},{"key":"e_1_2_10_13_1","unstructured":"Fairnie I. 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