{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:58Z","timestamp":1772160898033,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In ruminants, the overgrowth of offspring produced by in\u00a0vitro fertilization (IVF) is a common problem. Abnormal epigenetic modifications caused by environmental factors during the early embryonic period are suspected as an aetiology of overgrowth. In this study, we investigated the genome\u2010wide histone H3K4me3 profiles of bovine placentae that play a pivotal role in foetal development and compared their characteristics between artificial insemination (AI)\u2010 and IVF\u2010derived samples. Cotyledons were harvested from the placentae obtained at parturition of 5 AI\u2010 and 13 IVF\u2010derived calves, and chromatin immunoprecipitation sequencing was performed for H3K4me3. We confirmed no significant maternal tissue contamination in the samples we used. The revealed H3K4me3 profiles reflected the general characteristics of the H3K4me3 modification, which is abundantly distributed in the promoter region of active genes. By extracting common modifications from multiple samples, the genes involved in placenta\u2010specific biological processes could be enriched. Comparison with the H3K4me3 modifications of blastocyst samples was also effective for enriching the placenta\u2010specific features. Principal component analysis suggested the presence of differential H3K4me3 modifications in AI\u2010 and IVF\u2010derived samples. The genes contributing to the difference were related to the developmental biological processes. Imprinted genes such as\n                    <jats:italic>BEGAIN<\/jats:italic>\n                    ,\n                    <jats:italic>ZNF215<\/jats:italic>\n                    and\n                    <jats:italic>DLX5<\/jats:italic>\n                    were among the extracted genes. Principal component and discriminant analyses using only male samples categorized the samples into three groups based on foetal weight and calf\u2010production methods. To our knowledge, this is the first study to profile the genome\u2010wide histone modifications of bovine foetal placentae and reveal their differential characteristics between different calf\u2010production methods.\n                  <\/jats:p>","DOI":"10.1111\/rda.14527","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T03:06:07Z","timestamp":1704769567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of histone\n                    <scp>H3K4me3<\/scp>\n                    modifications in bovine placenta derived from different calf\u2010production methods"],"prefix":"10.1111","volume":"59","author":[{"given":"Kanoko","family":"Hattori","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Biology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kachi","sequence":"additional","affiliation":[{"name":"Dairy Research Department Gifu Prefectural Livestock Research Institute  Ena, Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumitsu","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Animal Science Tottori Livestock Research Center  Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Livestock Technology Research Center Hiroshima Prefectural Technology Research Institute  Shobara, Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinnosuke","family":"Honda","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naojiro","family":"Minami","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-2135","authenticated-orcid":false,"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, Graduate School of Agriculture Kyoto University  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0066"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016867"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1422088112"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201013012\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.24655"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102052.2008.01740.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00277"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.043919"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn923"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087683\u20100"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022100\u20108"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100201\u20104"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20107580.1997.19140517.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401866101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20100512\u20106_4"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102156\u201011\u201093"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.028"},{"key":"e_1_2_9_22_1","unstructured":"National Agriculture and Food Research Organization. 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