{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:38:41Z","timestamp":1791268721271,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Reprod Domestic Animals"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pregnancy toxaemia is a serious disease that occurs during the last trimester of pregnancy in sheep. Yet, in most cases, the disease may have a subclinical course. This study was aimed at comparing blood \u03b2HBA measurement devices for diagnosis of subclinical pregnancy toxaemia in late pregnant sheep. In the study, a total of 50 blood samples were collected from Romanov (<jats:italic>n<\/jats:italic>\u2009=\u200930) and cross\u2010bred Hamdani (<jats:italic>n<\/jats:italic>\u2009=\u200920) sheep. Blood \u03b2HBA levels were measured using TaiDoc TD\u20104235 and CentriVet \u03b2HBA hand\u2010held meter. Randox \u03b2HBA (Ranbut) assay was used as a reference laboratory method to compare hand\u2010held meters. \u03b2HBA value of 0.8\u2009mmol\/L was set as the cut\u2010off value for diagnosis of subclinical pregnancy toxaemia. Statistical analyses were carried out using Minitab 21 and Jamovi software. In the study, the correlation of Randox\u2010TaiDoc TD\u20104235 and Randox\u2010CentriVet was .822 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and .728 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), respectively. Based on the Ranbut assay, nine ewes out of 50 were diagnosed with subclinical pregnancy toxaemia. Specificity (detection of healthy ewes) and sensitivity (detection of ewes with subclinical pregnancy toxaemia) for TaiDoc TD\u20104235 and CentriVet hand\u2010held meters were 100%, 77.8%, and 100%, 66.7%, respectively. In the receiver operating characteristic (ROC) analysis, areas under the ROC curve (AUC) were 0.976 and 0.920 for TaiDoc and CentriVet, respectively. Bland\u2013Altman analysis revealed a bias of 0.092\u2009mmol\/L for TaiDoc and a bias of 0.132\u2009mmol\/L for CentriVet. TaiDoc hand\u2010held meter shows a better correlation with the Randox Ranbut assay and greater sensitivity compared to the CentriVet hand\u2010held meter. In conclusion, both TaiDoc and CentriVet hand\u2010held meters can be securely used in the diagnosis of subclinical pregnancy toxaemia in sheep. For these reasons, subclinical pregnancy toxaemia and these devices will be evaluated within the scope of herd management programme in the sheep industry. It should also be taken into account that these conditions will affect the future fertility of the mother and offspring.<\/jats:p>","DOI":"10.1111\/rda.14589","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T10:59:54Z","timestamp":1717066794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of blood <scp>\u0392HBA<\/scp> measurement devices for diagnosis of subclinical pregnancy toxaemia in sheep: A field study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-0939","authenticated-orcid":false,"given":"Ali Osman","family":"Turgut","sequence":"first","affiliation":[{"name":"Department of Animal Science, Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-6959","authenticated-orcid":false,"given":"Davut","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Van Yuzuncu Yil University  Van Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-7387","authenticated-orcid":false,"given":"Ali","family":"\u00dcnver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine Siirt University  Siirt Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.30607\/kvj.1310055"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.31893\/jabb.22030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2016\u201011077"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"Beigh S. 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Hussain S. &Nisar M.(2022).Effect of Butaphosphan and Cyanocobalamin on the Metabolic Profile Oxidative Stress Trace Minerals and Prophylaxis of Ovine Pregnancy Toxemia.https:\/\/doi.org\/10.21203\/rs.3.rs\u20101587889\/v1","DOI":"10.21203\/rs.3.rs-1587889\/v1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvfa.2010.10.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2014.971083"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5455\/ajvs.26377"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010022\u201004892\u20109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2005.10.010"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u2010165X.2008.00076.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/dairy2040052"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.05.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00069"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14486"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/rda.14542"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.17221\/5921-CJAS"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.1056S29"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.47611\/jsr.v8i2.799"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13223536"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.2.01840364"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2011.06.019"},{"key":"e_1_2_9_23_1","first-page":"197","article-title":"Evaluation of a portable ketometer for on\u2010site monitoring of blood \u03b2\u2010hydroxybutyrate concentrations in dairy sheep and goats","volume":"169","author":"Panousis N.","year":"2018","journal-title":"Revue de M\u00e9decine V\u00e9t\u00e9rinaire"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013\u20107169"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0749\u20100720(15)30107\u20109"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.254.7.859"},{"key":"e_1_2_9_27_1","unstructured":"Sjoberg A. &Van Saun R. 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