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Their unique biological traits, including induced ovulation and a reproductive process that closely mirrors that of humans, have been pivotal in their use as a model. Moreover, their body size is perfectly aligned with the 3Rs principles: Replacement, Reduction, and Refinement. Consequently, techniques for gamete collection and embryo recovery, followed by their use in artificial insemination or embryo transfer, are characterized by being minimally invasive. However, refining in\u00a0vitro fertilization and embryo culture techniques continues to present challenges. The incorporation of cutting\u2010edge genomic editing tools, such as CRISPR\/Cas9, has reestablished rabbits as essential models in genetic and biomedical research, driving scientific progress. This review aims to describe the most effective reproductive biotechnologies for both male and female rabbits and how these methodologies are in line with the 3Rs principles\u2014Replacement, Reduction, and Refinement\u2014highlighting their significance in conducting ethical research.<\/jats:p>","DOI":"10.1111\/rda.14640","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T01:28:11Z","timestamp":1728869291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Why choose the rabbit to work in reproductive technology?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-4118","authenticated-orcid":false,"given":"Francisco","family":"Marco\u2010Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda Animal Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-4035","authenticated-orcid":false,"given":"Mar\u00eda Pilar","family":"Viudes\u2010de\u2010Castro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Tecnolog\u00eda Animal Instituto Valenciano de Investigaciones Agrarias  Segorbe Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Salvador","family":"Vicente","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda Animal Universitat Polit\u00e8cnica de Val\u00e8ncia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136849"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2013.09.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD15553"},{"key":"e_1_2_12_5_1","first-page":"173","article-title":"Desarrollo folicular en la coneja","volume":"103","author":"Arias\u2010\u00c1lvarez M.","year":"2007","journal-title":"ITEA"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1998.tb00861.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120020108"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod12.2.260"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2015.08.003"},{"key":"e_1_2_12_10_1","unstructured":"Castillo J. 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